Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when cholesterol binds to the N-terminal domain (NTD) of NPC1, which projec...

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Bibliographic Details
Main Authors: Michael Nguyen Trinh, Michael S Brown, Joachim Seemann, Joseph L Goldstein, Feiran Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
NPC1 fragments
cholesterol transport
reconstitution
split nanoluciferase
lysosome
Online Access:https://elifesciences.org/articles/38564

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