The LANCA three-component reaction to highly substituted β-ketoenamides – versatile intermediates for the synthesis of functionalized pyridine, pyrimidine, oxazole and quinoxaline derivatives

The LANCA three-component reaction to highly substituted β-ketoenamides – versatile intermediates for the synthesis of functionalized pyridine, pyrimidine, oxazole and quinoxaline derivatives

The LANCA three-component reaction of lithiated alkoxyallenes LA, nitriles N and carboxylic acids CA leads to β-ketoenamides KE in good to excellent yields. The scope of this reaction is very broad and almost all types of nitriles and carboxylic acids have successfully been used. The alkoxy group in...

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Bibliographic Details
Main Authors: Tilman Lechel, Roopender Kumar, Mrinal K. Bera, Reinhold Zimmer, Hans-Ulrich Reissig
Format: Article
Language:English
Published: Beilstein-Institut 2019-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
allenes
condensations
multicomponent reactions
oxazoles
pyrimidines
quinoxalines
Online Access:https://doi.org/10.3762/bjoc.15.61

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