Emerging role for interferons in respiratory viral infections and childhood asthma
Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Decades of research has focused on the role of type I interferons in antivir...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1109001/full |
| _version_ | 1828010926217887744 |
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| author | Anthony Bosco Anthony Bosco |
| author_facet | Anthony Bosco Anthony Bosco |
| author_sort | Anthony Bosco |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Decades of research has focused on the role of type I interferons in antiviral immunity and ensuing airway diseases, however, recent findings have highlighted several novel aspects of the interferon response that merit further investigation. In this perspective, we discuss emerging roles of type I interferons in the pathogenesis of sLRI in children. We propose that variations in interferon response patterns exist as discrete endotypes, which operate locally in the airways and systemically through a lung-blood-bone marrow axis. We discuss new insights into the role of interferons in immune training, bacterial lysate immunotherapy, and allergen-specific immunotherapy. Interferons play complex and diverse roles in the pathogenesis of sLRI and later asthma, providing new directions for mechanistic studies and drug development. |
| first_indexed | 2024-04-10T09:07:32Z |
| format | Article |
| id | doaj.art-48c4d7de0c4d4c38b0cb2225af0ee42d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T09:07:32Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-48c4d7de0c4d4c38b0cb2225af0ee42d2023-02-21T05:15:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11090011109001Emerging role for interferons in respiratory viral infections and childhood asthmaAnthony Bosco0Anthony Bosco1Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United StatesDepartment of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, United StatesRespiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Decades of research has focused on the role of type I interferons in antiviral immunity and ensuing airway diseases, however, recent findings have highlighted several novel aspects of the interferon response that merit further investigation. In this perspective, we discuss emerging roles of type I interferons in the pathogenesis of sLRI in children. We propose that variations in interferon response patterns exist as discrete endotypes, which operate locally in the airways and systemically through a lung-blood-bone marrow axis. We discuss new insights into the role of interferons in immune training, bacterial lysate immunotherapy, and allergen-specific immunotherapy. Interferons play complex and diverse roles in the pathogenesis of sLRI and later asthma, providing new directions for mechanistic studies and drug development.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1109001/fullrhinovirusrespiratory syncytial viruschildhood asthmainterferonsinnate immunitytrained immunity |
| spellingShingle | Anthony Bosco Anthony Bosco Emerging role for interferons in respiratory viral infections and childhood asthma Frontiers in Immunology rhinovirus respiratory syncytial virus childhood asthma interferons innate immunity trained immunity |
| title | Emerging role for interferons in respiratory viral infections and childhood asthma |
| title_full | Emerging role for interferons in respiratory viral infections and childhood asthma |
| title_fullStr | Emerging role for interferons in respiratory viral infections and childhood asthma |
| title_full_unstemmed | Emerging role for interferons in respiratory viral infections and childhood asthma |
| title_short | Emerging role for interferons in respiratory viral infections and childhood asthma |
| title_sort | emerging role for interferons in respiratory viral infections and childhood asthma |
| topic | rhinovirus respiratory syncytial virus childhood asthma interferons innate immunity trained immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1109001/full |
| work_keys_str_mv | AT anthonybosco emergingroleforinterferonsinrespiratoryviralinfectionsandchildhoodasthma AT anthonybosco emergingroleforinterferonsinrespiratoryviralinfectionsandchildhoodasthma |