A Blood Bank Standardized Production of Human Platelet Lysate for Mesenchymal Stromal Cell Expansion: Proteomic Characterization and Biological Effects

A Blood Bank Standardized Production of Human Platelet Lysate for Mesenchymal Stromal Cell Expansion: Proteomic Characterization and Biological Effects

Human platelet lysate (hPL) is considered a valid substitute to fetal bovine serum (FBS) in the expansion of mesenchymal stromal cells (MSC), and it is commonly produced starting from intermediate side products of whole blood donations. Through freeze–thaw cycles, hPL is highly enriched in chemokine...

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Bibliographic Details
Main Authors: Andrea Bianchetti, Clizia Chinello, Michele Guindani, Simona Braga, Arabella Neva, Rosanna Verardi, Giovanna Piovani, Lisa Pagani, Gina Lisignoli, Fulvio Magni, Domenico Russo, Camillo Almici
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stromal cells
human platelet lysate
growth factors
mass spectrometry
blood banks standards
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.650490/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.650490/full

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