ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction
The complex microbial community in food environment is a major problem of human or animal health and safety. Mycotoxins and food-borne bacteria can both induce inflammation in the body and cause a series of changes in biological functions. In this study, mice were gavaged with low doses of ZEA, DON,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-05-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322003104 |
| _version_ | 1818047124425670656 |
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| author | Guodong Cai Fang Zhong Qianying Cao Yuni Bai Hui Zou Jianhong Gu Yan Yuan Guoqiang Zhu Zongping Liu Jianchun Bian |
| author_facet | Guodong Cai Fang Zhong Qianying Cao Yuni Bai Hui Zou Jianhong Gu Yan Yuan Guoqiang Zhu Zongping Liu Jianchun Bian |
| author_sort | Guodong Cai |
| collection | DOAJ |
| description | The complex microbial community in food environment is a major problem of human or animal health and safety. Mycotoxins and food-borne bacteria can both induce inflammation in the body and cause a series of changes in biological functions. In this study, mice were gavaged with low doses of ZEA, DON, or ZEA + DON, and then infected with L. monocytogenes. A cytokine microarray, including 40 inflammation-related serum cytokines, and proteomics were used to verify the effects of ZEA, DON, and ZEA + DON on the host inflammation and biological function after L. monocytogenes infection. The results showed that mononucleosis after bacterial infection was inhibited by ZEA, DON, and ZEA + DON, while the balance of macrophage differentiation was shifted toward M2-type. ZEA, DON, and ZEA + DON decreased the levels of serum proinflammatory cytokines IL-1β and IL-12 after infection. In addition, the signal of the NF-κB pathway was inhibited. Proteomic results showed that ZEA, DON, and ZEA + DON led to biological dysfunction in ribosomal and metabolic cells, primarily leading to abnormal ribosomal hyperfunction. This study showed that ZEA, DON, and ZEA + DON can aggravate disease progression by inhibiting the inflammatory response following foodborne bacterial infection. These metabolites may also disrupt normal biological functions, which may lead to ribosomal hyperfunction, making bacterial clearance more difficult. |
| first_indexed | 2024-12-10T10:00:48Z |
| format | Article |
| id | doaj.art-48c6a76059854a42b31625f7cd5206ef |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-10T10:00:48Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-48c6a76059854a42b31625f7cd5206ef2022-12-22T01:53:21ZengElsevierEcotoxicology and Environmental Safety0147-65132022-05-01236113470ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunctionGuodong Cai0Fang Zhong1Qianying Cao2Yuni Bai3Hui Zou4Jianhong Gu5Yan Yuan6Guoqiang Zhu7Zongping Liu8Jianchun Bian9College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China; Corresponding author at: College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.The complex microbial community in food environment is a major problem of human or animal health and safety. Mycotoxins and food-borne bacteria can both induce inflammation in the body and cause a series of changes in biological functions. In this study, mice were gavaged with low doses of ZEA, DON, or ZEA + DON, and then infected with L. monocytogenes. A cytokine microarray, including 40 inflammation-related serum cytokines, and proteomics were used to verify the effects of ZEA, DON, and ZEA + DON on the host inflammation and biological function after L. monocytogenes infection. The results showed that mononucleosis after bacterial infection was inhibited by ZEA, DON, and ZEA + DON, while the balance of macrophage differentiation was shifted toward M2-type. ZEA, DON, and ZEA + DON decreased the levels of serum proinflammatory cytokines IL-1β and IL-12 after infection. In addition, the signal of the NF-κB pathway was inhibited. Proteomic results showed that ZEA, DON, and ZEA + DON led to biological dysfunction in ribosomal and metabolic cells, primarily leading to abnormal ribosomal hyperfunction. This study showed that ZEA, DON, and ZEA + DON can aggravate disease progression by inhibiting the inflammatory response following foodborne bacterial infection. These metabolites may also disrupt normal biological functions, which may lead to ribosomal hyperfunction, making bacterial clearance more difficult.http://www.sciencedirect.com/science/article/pii/S0147651322003104ZearalenoneDeoxynivalenolListeria monocytogenesInflammationRibosomal hyperfunction |
| spellingShingle | Guodong Cai Fang Zhong Qianying Cao Yuni Bai Hui Zou Jianhong Gu Yan Yuan Guoqiang Zhu Zongping Liu Jianchun Bian ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction Ecotoxicology and Environmental Safety Zearalenone Deoxynivalenol Listeria monocytogenes Inflammation Ribosomal hyperfunction |
| title | ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction |
| title_full | ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction |
| title_fullStr | ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction |
| title_full_unstemmed | ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction |
| title_short | ZEA and DON inhibited inflammation after L. monocytogenes infection and induced ribosomal hyperfunction |
| title_sort | zea and don inhibited inflammation after l monocytogenes infection and induced ribosomal hyperfunction |
| topic | Zearalenone Deoxynivalenol Listeria monocytogenes Inflammation Ribosomal hyperfunction |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322003104 |
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