Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study
The goal of this study was to analyse the effects of percutaneous application of platelet rich plasma (PRP), autologous bone marrow concentrate (BM) and chitosan gel (CHI) on bone consolidation following minimally invasive plate osteosynthesis (MIPO) of the fractures of the tibia in dogs. Client-own...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2019-07-01
|
| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201907-0004_platelet-rich-plasma-bone-marrow-and-chitosan-in-minimally-invasive-plate-osteosynthesis-of-canine-tibia-fract.php |
| _version_ | 1828006558797135872 |
|---|---|
| author | Fabricia Geovania Fernandes Filgueira Bruno Watanabe Minto Denise Granato Chung Tiago Carmagni Prada Natalie Massaro Rosa-Ballaben Maria Gabriela Nogueira Campos |
| author_facet | Fabricia Geovania Fernandes Filgueira Bruno Watanabe Minto Denise Granato Chung Tiago Carmagni Prada Natalie Massaro Rosa-Ballaben Maria Gabriela Nogueira Campos |
| author_sort | Fabricia Geovania Fernandes Filgueira |
| collection | DOAJ |
| description | The goal of this study was to analyse the effects of percutaneous application of platelet rich plasma (PRP), autologous bone marrow concentrate (BM) and chitosan gel (CHI) on bone consolidation following minimally invasive plate osteosynthesis (MIPO) of the fractures of the tibia in dogs. Client-owned dogs (n = 30) with tibial fracture were divided into four treatment groups - Group 1 (control), Group 2 (BM), Group 3 (PRP) and Group 4 (CHI). The biomaterial specific to each group was injected at the fracture site immediately after the MIPO procedure. Serial radiographs were used to determine the fracture line and the development of periosteal callus immediately after surgery and at 15, 30, 60, 90 and 120 days post-surgery. There was no significant difference (P > 0.05) in the degree of oedema or grade of lameness between the groups. Grade 4 (minimum) or 5 lameness (absent) was observed in 70% of animals from all groups at 15 days post-surgery. The biomaterials PRP, BM and CHI combined with MIPO contribute to bone consolidation of tibial fractures in dogs and do not cause adverse reactions or fracture complications. Bone marrow concentrate results in shorter bone consolidation time. |
| first_indexed | 2024-04-10T07:58:25Z |
| format | Article |
| id | doaj.art-48c81187ea9745c9abbf29b214db2e8c |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:58:25Z |
| publishDate | 2019-07-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-48c81187ea9745c9abbf29b214db2e8c2023-02-23T03:50:53ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922019-07-0164730931610.17221/19/2019-VETMEDvet-201907-0004Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized studyFabricia Geovania Fernandes Filgueira0Bruno Watanabe Minto1Denise Granato Chung2Tiago Carmagni Prada3Natalie Massaro Rosa-Ballaben4Maria Gabriela Nogueira Campos5Veterinary Hospital Adílio Santos de Azevedo, Federal Institute of Education, Science and Technology of Paraíba, Sousa, Paraiba, BrazilDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Universidade Estadual Paulista, Jaboticabal, São Paulo, BrazilDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Universidade Estadual Paulista, Jaboticabal, São Paulo, BrazilDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Universidade Estadual Paulista, Jaboticabal, São Paulo, BrazilDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Universidade Estadual Paulista, Jaboticabal, São Paulo, BrazilInstitute of Science and Technology, Federal University of Alfenas, Campus Poços de Caldas, Alfenas, Minas Gerais, BrazilThe goal of this study was to analyse the effects of percutaneous application of platelet rich plasma (PRP), autologous bone marrow concentrate (BM) and chitosan gel (CHI) on bone consolidation following minimally invasive plate osteosynthesis (MIPO) of the fractures of the tibia in dogs. Client-owned dogs (n = 30) with tibial fracture were divided into four treatment groups - Group 1 (control), Group 2 (BM), Group 3 (PRP) and Group 4 (CHI). The biomaterial specific to each group was injected at the fracture site immediately after the MIPO procedure. Serial radiographs were used to determine the fracture line and the development of periosteal callus immediately after surgery and at 15, 30, 60, 90 and 120 days post-surgery. There was no significant difference (P > 0.05) in the degree of oedema or grade of lameness between the groups. Grade 4 (minimum) or 5 lameness (absent) was observed in 70% of animals from all groups at 15 days post-surgery. The biomaterials PRP, BM and CHI combined with MIPO contribute to bone consolidation of tibial fractures in dogs and do not cause adverse reactions or fracture complications. Bone marrow concentrate results in shorter bone consolidation time.https://vetmed.agriculturejournals.cz/artkey/vet-201907-0004_platelet-rich-plasma-bone-marrow-and-chitosan-in-minimally-invasive-plate-osteosynthesis-of-canine-tibia-fract.phpbone consolidationsurgerybiomaterialsdogspercutaneous application |
| spellingShingle | Fabricia Geovania Fernandes Filgueira Bruno Watanabe Minto Denise Granato Chung Tiago Carmagni Prada Natalie Massaro Rosa-Ballaben Maria Gabriela Nogueira Campos Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study Veterinární Medicína bone consolidation surgery biomaterials dogs percutaneous application |
| title | Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study |
| title_full | Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study |
| title_fullStr | Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study |
| title_full_unstemmed | Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study |
| title_short | Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study |
| title_sort | platelet rich plasma bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures a randomized study |
| topic | bone consolidation surgery biomaterials dogs percutaneous application |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201907-0004_platelet-rich-plasma-bone-marrow-and-chitosan-in-minimally-invasive-plate-osteosynthesis-of-canine-tibia-fract.php |
| work_keys_str_mv | AT fabriciageovaniafernandesfilgueira plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy AT brunowatanabeminto plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy AT denisegranatochung plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy AT tiagocarmagniprada plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy AT nataliemassarorosaballaben plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy AT mariagabrielanogueiracampos plateletrichplasmabonemarrowandchitosaninminimallyinvasiveplateosteosynthesisofcaninetibiafracturesarandomizedstudy |