Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine
While neutralizing antibody titers measured by hemagglutination inhibition have been proposed as a correlate of protection following influenza vaccination, neutralization alone is a modest predictor of protection against seasonal influenza. Instead, emerging data point to a critical role for additio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00440/full |
| _version_ | 1818135051169169408 |
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| author | Carolyn M. Boudreau Carolyn M. Boudreau Galit Alter |
| author_facet | Carolyn M. Boudreau Carolyn M. Boudreau Galit Alter |
| author_sort | Carolyn M. Boudreau |
| collection | DOAJ |
| description | While neutralizing antibody titers measured by hemagglutination inhibition have been proposed as a correlate of protection following influenza vaccination, neutralization alone is a modest predictor of protection against seasonal influenza. Instead, emerging data point to a critical role for additional extra-neutralizing functions of antibodies in protection from infection. Specifically, beyond binding and neutralization, antibodies mediate a variety of additional immune functions via their ability to recruit and deploy innate immune effector function. Along these lines, antibody-dependent cellular cytotoxicity, antibody-mediated macrophage phagocytosis and activation, antibody-driven neutrophil activation, antibody-dependent complement deposition, and non-classical Fc-receptor antibody trafficking have all been implicated in protection from influenza infection. However, the precise mechanism(s) by which the immune system actively tunes antibody functionality to drive protective immunity has been poorly characterized. Here we review the data related to Fc-effector functional protection from influenza and discuss prospects to leverage this humoral immune activity for the development of a universal influenza vaccine. |
| first_indexed | 2024-12-11T09:18:22Z |
| format | Article |
| id | doaj.art-48c8241ac8f542d4855b194081ce8f2d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T09:18:22Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-48c8241ac8f542d4855b194081ce8f2d2022-12-22T01:13:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00440442776Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza VaccineCarolyn M. Boudreau0Carolyn M. Boudreau1Galit Alter2Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United StatesHarvard Ph.D. Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, United StatesRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, United StatesWhile neutralizing antibody titers measured by hemagglutination inhibition have been proposed as a correlate of protection following influenza vaccination, neutralization alone is a modest predictor of protection against seasonal influenza. Instead, emerging data point to a critical role for additional extra-neutralizing functions of antibodies in protection from infection. Specifically, beyond binding and neutralization, antibodies mediate a variety of additional immune functions via their ability to recruit and deploy innate immune effector function. Along these lines, antibody-dependent cellular cytotoxicity, antibody-mediated macrophage phagocytosis and activation, antibody-driven neutrophil activation, antibody-dependent complement deposition, and non-classical Fc-receptor antibody trafficking have all been implicated in protection from influenza infection. However, the precise mechanism(s) by which the immune system actively tunes antibody functionality to drive protective immunity has been poorly characterized. Here we review the data related to Fc-effector functional protection from influenza and discuss prospects to leverage this humoral immune activity for the development of a universal influenza vaccine.https://www.frontiersin.org/article/10.3389/fimmu.2019.00440/fullinfluenzaantibodyFc receptorvaccineADCCglycosylation |
| spellingShingle | Carolyn M. Boudreau Carolyn M. Boudreau Galit Alter Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine Frontiers in Immunology influenza antibody Fc receptor vaccine ADCC glycosylation |
| title | Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine |
| title_full | Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine |
| title_fullStr | Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine |
| title_full_unstemmed | Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine |
| title_short | Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine |
| title_sort | extra neutralizing fcr mediated antibody functions for a universal influenza vaccine |
| topic | influenza antibody Fc receptor vaccine ADCC glycosylation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00440/full |
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