Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease
Abstract Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease and the third leading cause of death worldwide. Developments in next‐generation sequencing technology have improved microbiome analysis, which is increasingly recognized as an important component of disease...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Chronic Diseases and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cdt3.66 |
| _version_ | 1797808872665120768 |
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| author | Yixing Zhu De Chang |
| author_facet | Yixing Zhu De Chang |
| author_sort | Yixing Zhu |
| collection | DOAJ |
| description | Abstract Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease and the third leading cause of death worldwide. Developments in next‐generation sequencing technology have improved microbiome analysis, which is increasingly recognized as an important component of disease management. Similar to the gut, the lung is a biosphere containing billions of microbial communities. The lung microbiome plays an important role in regulating and maintaining the host immune system. The microbiome composition, metabolites of microorganisms, and the interactions between the lung microbiome and the host immunity profoundly affect the occurrence, development, treatment, and prognosis of COPD. In this review, we drew comparisons between the lung microbiome of healthy individuals and that of patients with COPD. Furthermore, we summarize the intrinsic interactions between the host and the overall lung microbiome, focusing on the underlying mechanisms linking the microbiome to the host innate and adaptive immune response pathways. Finally, we discuss the possibility of using the microbiome as a biomarker to determine the stage and prognosis of COPD and the feasibility of developing a novel, safe, and effective therapeutic target. |
| first_indexed | 2024-03-13T06:44:07Z |
| format | Article |
| id | doaj.art-48c84d50219f4e6b8ee534b5a7a22179 |
| institution | Directory Open Access Journal |
| issn | 2589-0514 |
| language | English |
| last_indexed | 2024-03-13T06:44:07Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-48c84d50219f4e6b8ee534b5a7a221792023-06-08T11:29:25ZengWileyChronic Diseases and Translational Medicine2589-05142023-06-019210412110.1002/cdt3.66Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary diseaseYixing Zhu0De Chang1Graduate School of The PLA General Hospital Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Eighth Medical Center, Department of Respiratory and Critical Care Seventh Medical Center Chinese PLA General Hospital Beijing ChinaAbstract Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease and the third leading cause of death worldwide. Developments in next‐generation sequencing technology have improved microbiome analysis, which is increasingly recognized as an important component of disease management. Similar to the gut, the lung is a biosphere containing billions of microbial communities. The lung microbiome plays an important role in regulating and maintaining the host immune system. The microbiome composition, metabolites of microorganisms, and the interactions between the lung microbiome and the host immunity profoundly affect the occurrence, development, treatment, and prognosis of COPD. In this review, we drew comparisons between the lung microbiome of healthy individuals and that of patients with COPD. Furthermore, we summarize the intrinsic interactions between the host and the overall lung microbiome, focusing on the underlying mechanisms linking the microbiome to the host innate and adaptive immune response pathways. Finally, we discuss the possibility of using the microbiome as a biomarker to determine the stage and prognosis of COPD and the feasibility of developing a novel, safe, and effective therapeutic target.https://doi.org/10.1002/cdt3.66adaptive immune responsechronic obstructive pulmonary diseaseinnate immune responsemicrobiome |
| spellingShingle | Yixing Zhu De Chang Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease Chronic Diseases and Translational Medicine adaptive immune response chronic obstructive pulmonary disease innate immune response microbiome |
| title | Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| title_full | Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| title_fullStr | Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| title_full_unstemmed | Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| title_short | Interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| title_sort | interactions between the lung microbiome and host immunity in chronic obstructive pulmonary disease |
| topic | adaptive immune response chronic obstructive pulmonary disease innate immune response microbiome |
| url | https://doi.org/10.1002/cdt3.66 |
| work_keys_str_mv | AT yixingzhu interactionsbetweenthelungmicrobiomeandhostimmunityinchronicobstructivepulmonarydisease AT dechang interactionsbetweenthelungmicrobiomeandhostimmunityinchronicobstructivepulmonarydisease |