Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran
Objective: To determine the seroprevalance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population of Mazandaran province in Iran and to estimate the percentage of asymptomatic, mild, and severe infections. Methods: We chose 1 588 inhabitants of Mazandara...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=10;epage=16;aulast=Mousavi |
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| author | Seyed Abbas Mousavi Hamed Rouhanizadeh Majid Saeedi Mahmood Moosazadeh Abolqasem Ajami Afsaneh Fendereski Jamshid Yazdani-Charati Seyed Mohsen Soleimani Nader Ahangar Seyed Hossein Seyedpour Zahra Bandalizaeh |
| author_facet | Seyed Abbas Mousavi Hamed Rouhanizadeh Majid Saeedi Mahmood Moosazadeh Abolqasem Ajami Afsaneh Fendereski Jamshid Yazdani-Charati Seyed Mohsen Soleimani Nader Ahangar Seyed Hossein Seyedpour Zahra Bandalizaeh |
| author_sort | Seyed Abbas Mousavi |
| collection | DOAJ |
| description | Objective: To determine the seroprevalance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population of Mazandaran province in Iran and to estimate the percentage of asymptomatic, mild, and severe infections.
Methods: We chose 1 588 inhabitants of Mazandaran province with cluster sampling. We measured their SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) serum levels. Demographics, risk factors, and symptoms were collected. The seroprevalence of SARS-CoV-2 was calculated by age and city and the World Health Organization (WHO) protocol and further stratified by demographic variables and risk factors. Finally, we identified the symptoms and factors related to COVID-19 with logistic regression.
Results: Two hundred subjects (12.59%) were tested positive for either IgG or IgM. Until May 23, 2020, the prevalence of COVID-19 was 15.26% (95% CI: 12.97%-17.79%) based on direct standardization and WHO’s standardized age groups. Based on multivariate logistic regression, the incidence of getting an infection increased by an average of 11.6% for every 10-year increase in age (OR=1.116, 95% CI: 1.008-1.236, P=0.035). Furthermore, those in contact with COVID-19 patients had a 66.1% higher risk of developing the disease (OR=1.661, 95% CI: 1.104-2.497, P=0.015). In addition, the chance of getting SARS-CoV-2 infection was almost four times higher in people who had consulted a doctor during the pandemic than those who had not (OR=3.942, 95% CI: 2.813-5.524, P<0.001).
Conclusions: The prevalence of COVID-19 in Mazandaran province could be higher than the officially reported statistics based on diagnostic tests and clinical cases. There seems to be more asymptomatic or mild symptom cases than what was previously reported. |
| first_indexed | 2024-04-11T21:25:41Z |
| format | Article |
| id | doaj.art-48cb4fc3983b49ac8c3c9fea44fc7160 |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-04-11T21:25:41Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-48cb4fc3983b49ac8c3c9fea44fc71602022-12-22T04:02:24ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462021-01-01141101610.4103/1995-7645.304296Seroprevalence of SARS-CoV-2 in Mazandaran province, IranSeyed Abbas MousaviHamed RouhanizadehMajid SaeediMahmood MoosazadehAbolqasem AjamiAfsaneh FendereskiJamshid Yazdani-CharatiSeyed Mohsen SoleimaniNader AhangarSeyed Hossein SeyedpourZahra BandalizaehObjective: To determine the seroprevalance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population of Mazandaran province in Iran and to estimate the percentage of asymptomatic, mild, and severe infections. Methods: We chose 1 588 inhabitants of Mazandaran province with cluster sampling. We measured their SARS-CoV-2 immunoglobulin M (IgM) and immunoglobulin G (IgG) serum levels. Demographics, risk factors, and symptoms were collected. The seroprevalence of SARS-CoV-2 was calculated by age and city and the World Health Organization (WHO) protocol and further stratified by demographic variables and risk factors. Finally, we identified the symptoms and factors related to COVID-19 with logistic regression. Results: Two hundred subjects (12.59%) were tested positive for either IgG or IgM. Until May 23, 2020, the prevalence of COVID-19 was 15.26% (95% CI: 12.97%-17.79%) based on direct standardization and WHO’s standardized age groups. Based on multivariate logistic regression, the incidence of getting an infection increased by an average of 11.6% for every 10-year increase in age (OR=1.116, 95% CI: 1.008-1.236, P=0.035). Furthermore, those in contact with COVID-19 patients had a 66.1% higher risk of developing the disease (OR=1.661, 95% CI: 1.104-2.497, P=0.015). In addition, the chance of getting SARS-CoV-2 infection was almost four times higher in people who had consulted a doctor during the pandemic than those who had not (OR=3.942, 95% CI: 2.813-5.524, P<0.001). Conclusions: The prevalence of COVID-19 in Mazandaran province could be higher than the officially reported statistics based on diagnostic tests and clinical cases. There seems to be more asymptomatic or mild symptom cases than what was previously reported.http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=10;epage=16;aulast=Mousavisars-cov-2; covid-19; prevalance; iran; serology; igm; igg |
| spellingShingle | Seyed Abbas Mousavi Hamed Rouhanizadeh Majid Saeedi Mahmood Moosazadeh Abolqasem Ajami Afsaneh Fendereski Jamshid Yazdani-Charati Seyed Mohsen Soleimani Nader Ahangar Seyed Hossein Seyedpour Zahra Bandalizaeh Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran Asian Pacific Journal of Tropical Medicine sars-cov-2; covid-19; prevalance; iran; serology; igm; igg |
| title | Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran |
| title_full | Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran |
| title_fullStr | Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran |
| title_full_unstemmed | Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran |
| title_short | Seroprevalence of SARS-CoV-2 in Mazandaran province, Iran |
| title_sort | seroprevalence of sars cov 2 in mazandaran province iran |
| topic | sars-cov-2; covid-19; prevalance; iran; serology; igm; igg |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=10;epage=16;aulast=Mousavi |
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