Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease
Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124000564 |
| _version_ | 1827325487426306048 |
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| author | Daye Baek Kun-Gu Lee Hee-Young Sohn Jung Hyun Park Hye-Kyung Lee Govigerel Bayarsaikhan Sang-Won Yoo Bonghee Lee Joong-Seok Kim Young Ho Koh Munjin Kwon |
| author_facet | Daye Baek Kun-Gu Lee Hee-Young Sohn Jung Hyun Park Hye-Kyung Lee Govigerel Bayarsaikhan Sang-Won Yoo Bonghee Lee Joong-Seok Kim Young Ho Koh Munjin Kwon |
| author_sort | Daye Baek |
| collection | DOAJ |
| description | Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers. |
| first_indexed | 2024-03-07T14:29:56Z |
| format | Article |
| id | doaj.art-48cc1116df1640b6bc45b8fb6ae64567 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-07T14:29:56Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-48cc1116df1640b6bc45b8fb6ae645672024-03-06T05:26:27ZengElsevierStem Cell Research1873-50612024-04-0176103358Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's diseaseDaye Baek0Kun-Gu Lee1Hee-Young Sohn2Jung Hyun Park3Hye-Kyung Lee4Govigerel Bayarsaikhan5Sang-Won Yoo6Bonghee Lee7Joong-Seok Kim8Young Ho Koh9Munjin Kwon10Department of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of KoreanSAGE Inc., Incheon, Republic of KoreaDepartment of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea; Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of KoreaDepartment of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of KoreaDepartment of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of KoreaDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreanSAGE Inc., Incheon, Republic of Korea; Department of Anatomy and Cell Biology, Gachon University Graduate School of Medicine, Center for Regenerative Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of KoreaDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of KoreaDepartment of Chronic Disease Convergence Research, Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea; Corresponding author.Parkinson's disease is a degenerative brain disorder characterized by dopamine neuronal degeneration and dopamine transporter loss. In this study, we generated an induced pluripotent stem cell (iPSC) line, KNIHi001-A, from the peripheral blood mononuclear cells (PBMCs) of a 76-year-old man with Parkinson's disease. The non-integrating Sendai virus was used to reprogram iPSCs. iPSCs exhibit pluripotent markers, a normal karyotype, viral clearance, and the ability to differentiate into the three germ layers.http://www.sciencedirect.com/science/article/pii/S1873506124000564 |
| spellingShingle | Daye Baek Kun-Gu Lee Hee-Young Sohn Jung Hyun Park Hye-Kyung Lee Govigerel Bayarsaikhan Sang-Won Yoo Bonghee Lee Joong-Seok Kim Young Ho Koh Munjin Kwon Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease Stem Cell Research |
| title | Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease |
| title_full | Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease |
| title_fullStr | Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease |
| title_full_unstemmed | Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease |
| title_short | Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease |
| title_sort | generation of an induced pluripotent stem cell line knihi001 a by reprogramming peripheral blood mononuclear cells isolated from a patient with parkinson s disease |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124000564 |
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