Exploration of auditory P50 gating in schizophrenia by way of difference waves
<p>Abstract</p> <p>Electroencephalographic measures of information processing encompass both mid-latency evoked potentials like the pre-attentive auditory P50 potential and a host of later more cognitive components like P300 and N400.</p> <p>Difference waves have mostly...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-01-01
|
| Series: | Behavioral and Brain Functions |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/2/1/6 |
| _version_ | 1818002005791080448 |
|---|---|
| author | Arnfred Sidse M |
| author_facet | Arnfred Sidse M |
| author_sort | Arnfred Sidse M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Electroencephalographic measures of information processing encompass both mid-latency evoked potentials like the pre-attentive auditory P50 potential and a host of later more cognitive components like P300 and N400.</p> <p>Difference waves have mostly been employed in studies of later event related potentials but here this method along with low frequency filtering is applied exploratory on auditory P50 gating data, previously analyzed in the standard format (reported in <it>Am J Psychiatry </it>2003, <b>160</b>:2236-8). The exploration was motivated by the observation during visual peak detection that the AEP waveform was different in the patient group, although this was not reflected by the peak measures. The sample included un-medicated schizophrenia spectrum patients (n = 17) and healthy controls (n = 24). The patients had an attenuated difference P50. This attenuation was primarily seen in the sub-sample of patients with severe negative symptoms. The difference attenuation was due to low amplitude at the first stimulus. This suggests an abnormality in readiness more than an abnormality in gating in the patient group.</p> |
| first_indexed | 2024-04-14T03:41:20Z |
| format | Article |
| id | doaj.art-48ce11e6f6664669a2b714a2bd89a797 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-14T03:41:20Z |
| publishDate | 2006-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-48ce11e6f6664669a2b714a2bd89a7972022-12-22T02:14:31ZengBMCBehavioral and Brain Functions1744-90812006-01-0121610.1186/1744-9081-2-6Exploration of auditory P50 gating in schizophrenia by way of difference wavesArnfred Sidse M<p>Abstract</p> <p>Electroencephalographic measures of information processing encompass both mid-latency evoked potentials like the pre-attentive auditory P50 potential and a host of later more cognitive components like P300 and N400.</p> <p>Difference waves have mostly been employed in studies of later event related potentials but here this method along with low frequency filtering is applied exploratory on auditory P50 gating data, previously analyzed in the standard format (reported in <it>Am J Psychiatry </it>2003, <b>160</b>:2236-8). The exploration was motivated by the observation during visual peak detection that the AEP waveform was different in the patient group, although this was not reflected by the peak measures. The sample included un-medicated schizophrenia spectrum patients (n = 17) and healthy controls (n = 24). The patients had an attenuated difference P50. This attenuation was primarily seen in the sub-sample of patients with severe negative symptoms. The difference attenuation was due to low amplitude at the first stimulus. This suggests an abnormality in readiness more than an abnormality in gating in the patient group.</p>http://www.behavioralandbrainfunctions.com/content/2/1/6 |
| spellingShingle | Arnfred Sidse M Exploration of auditory P50 gating in schizophrenia by way of difference waves Behavioral and Brain Functions |
| title | Exploration of auditory P50 gating in schizophrenia by way of difference waves |
| title_full | Exploration of auditory P50 gating in schizophrenia by way of difference waves |
| title_fullStr | Exploration of auditory P50 gating in schizophrenia by way of difference waves |
| title_full_unstemmed | Exploration of auditory P50 gating in schizophrenia by way of difference waves |
| title_short | Exploration of auditory P50 gating in schizophrenia by way of difference waves |
| title_sort | exploration of auditory p50 gating in schizophrenia by way of difference waves |
| url | http://www.behavioralandbrainfunctions.com/content/2/1/6 |
| work_keys_str_mv | AT arnfredsidsem explorationofauditoryp50gatinginschizophreniabywayofdifferencewaves |