Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins
The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2006-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3124 |
| _version_ | 1797260794324320256 |
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| author | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Jovan Radovanović Emina Ićindić-Nakaš Mira Winterhalter-Jadrić |
| author_facet | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Jovan Radovanović Emina Ićindić-Nakaš Mira Winterhalter-Jadrić |
| author_sort | Radivoj Jadrić |
| collection | DOAJ |
| description |
The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.
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| first_indexed | 2024-04-24T23:30:59Z |
| format | Article |
| id | doaj.art-48d038aaa4b1420cbe49c64378c366c0 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:30:59Z |
| publishDate | 2006-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-48d038aaa4b1420cbe49c64378c366c02024-03-15T14:42:33ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2006-11-016410.17305/bjbms.2006.3124683Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphinsRadivoj Jadrić0Sabaheta Hasić1Emina Kiseljaković2Jovan Radovanović3Emina Ićindić-Nakaš4Mira Winterhalter-Jadrić5Institute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3124amitryptilinbeta-endorphinsratserabrain |
| spellingShingle | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Jovan Radovanović Emina Ićindić-Nakaš Mira Winterhalter-Jadrić Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins Biomolecules & Biomedicine amitryptilin beta-endorphins rat sera brain |
| title | Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins |
| title_full | Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins |
| title_fullStr | Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins |
| title_full_unstemmed | Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins |
| title_short | Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins |
| title_sort | effects of amitryptilin administration on rat sera and brain beta endorphins |
| topic | amitryptilin beta-endorphins rat sera brain |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3124 |
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