Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies
Epilepsy is one of the most common neurological disorders affecting people of all ages representing a significant social and public health burden. Current therapeutic options for epilepsy are not effective in a significant proportion of patients suggesting a need for identifying novel targets for th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1201971/full |
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| author | Eman A. Alraddadi Eman A. Alraddadi Abdulrahman M. Khojah Abdulrahman M. Khojah Faisal F. Alamri Faisal F. Alamri Husun K. Kecheck Husun K. Kecheck Wid F. Altaf Wid F. Altaf Yousef Khouqeer Yousef Khouqeer |
| author_facet | Eman A. Alraddadi Eman A. Alraddadi Abdulrahman M. Khojah Abdulrahman M. Khojah Faisal F. Alamri Faisal F. Alamri Husun K. Kecheck Husun K. Kecheck Wid F. Altaf Wid F. Altaf Yousef Khouqeer Yousef Khouqeer |
| author_sort | Eman A. Alraddadi |
| collection | DOAJ |
| description | Epilepsy is one of the most common neurological disorders affecting people of all ages representing a significant social and public health burden. Current therapeutic options for epilepsy are not effective in a significant proportion of patients suggesting a need for identifying novel targets for the development of more effective therapeutics. There is growing evidence from animal and human studies suggesting a role of impaired brain energy metabolism and mitochondrial dysfunction in the development of epilepsy. Candidate compounds with the potential to target brain energetics have promising future in the management of epilepsy and other related neurological disorders. Creatine is a naturally occurring organic compound that serves as an energy buffer and energy shuttle in tissues, such as brain and skeletal muscle, that exhibit dynamic energy requirements. In this review, applications of creatine supplements in neurological conditions in which mitochondrial dysfunction is a central component in its pathology will be discussed. Currently, limited evidence mainly from preclinical animal studies suggest anticonvulsant properties of creatine; however, the exact mechanism remain to be elucidated. Future work should involve larger clinical trials of creatine used as an add-on therapy, followed by large clinical trials of creatine as monotherapy. |
| first_indexed | 2024-03-13T02:34:08Z |
| format | Article |
| id | doaj.art-48d2cb0a8a5d420b8a6da54b02c4dfd0 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T02:34:08Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-48d2cb0a8a5d420b8a6da54b02c4dfd02023-06-29T09:37:36ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.12019711201971Potential role of creatine as an anticonvulsant agent: evidence from preclinical studiesEman A. Alraddadi0Eman A. Alraddadi1Abdulrahman M. Khojah2Abdulrahman M. Khojah3Faisal F. Alamri4Faisal F. Alamri5Husun K. Kecheck6Husun K. Kecheck7Wid F. Altaf8Wid F. Altaf9Yousef Khouqeer10Yousef Khouqeer11Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaEpilepsy is one of the most common neurological disorders affecting people of all ages representing a significant social and public health burden. Current therapeutic options for epilepsy are not effective in a significant proportion of patients suggesting a need for identifying novel targets for the development of more effective therapeutics. There is growing evidence from animal and human studies suggesting a role of impaired brain energy metabolism and mitochondrial dysfunction in the development of epilepsy. Candidate compounds with the potential to target brain energetics have promising future in the management of epilepsy and other related neurological disorders. Creatine is a naturally occurring organic compound that serves as an energy buffer and energy shuttle in tissues, such as brain and skeletal muscle, that exhibit dynamic energy requirements. In this review, applications of creatine supplements in neurological conditions in which mitochondrial dysfunction is a central component in its pathology will be discussed. Currently, limited evidence mainly from preclinical animal studies suggest anticonvulsant properties of creatine; however, the exact mechanism remain to be elucidated. Future work should involve larger clinical trials of creatine used as an add-on therapy, followed by large clinical trials of creatine as monotherapy.https://www.frontiersin.org/articles/10.3389/fnins.2023.1201971/fullcreatineepilepsyseizureantioxidantmitochondrial dysfunctionanticonvulsant |
| spellingShingle | Eman A. Alraddadi Eman A. Alraddadi Abdulrahman M. Khojah Abdulrahman M. Khojah Faisal F. Alamri Faisal F. Alamri Husun K. Kecheck Husun K. Kecheck Wid F. Altaf Wid F. Altaf Yousef Khouqeer Yousef Khouqeer Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies Frontiers in Neuroscience creatine epilepsy seizure antioxidant mitochondrial dysfunction anticonvulsant |
| title | Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies |
| title_full | Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies |
| title_fullStr | Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies |
| title_full_unstemmed | Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies |
| title_short | Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies |
| title_sort | potential role of creatine as an anticonvulsant agent evidence from preclinical studies |
| topic | creatine epilepsy seizure antioxidant mitochondrial dysfunction anticonvulsant |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1201971/full |
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