DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma.

DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma.

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Although osteosarcoma (OS) is a rare cancer, it is the most common primary malignant bone tumor in children and adolescents. BRCAness is a phenotypical trait in tumors with a defect in homologous recombination repair, resembling tumors with inactivation of BRCA1/2, rendering these tumors sensitive t...

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Bibliographic Details
Main Authors: Maxim Barenboim, Michal Kovac, Baptiste Ameline, David T W Jones, Olaf Witt, Stefan Bielack, Stefan Burdach, Daniel Baumhoer, Michaela Nathrath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1009562

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