Multifunctional surface functionalized magnetic iron oxide nanoparticles for biomedical applications: A review

Magnetic iron oxide nanoparticle-based multifunctional platforms have been explored extensively in biomedical applications. Modifications and integrations of IONPs with different entities viz. organic polymer, doping with inorganic materials, loading with drug, fluorescent dye, or antibodies make th...

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Bibliographic Details
Main Authors: Rutuja Prashant Gambhir, Sonali S Rohiwal, Arpita Pandey Tiwari
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Applied Surface Science Advances
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666523922000939
Description
Summary:Magnetic iron oxide nanoparticle-based multifunctional platforms have been explored extensively in biomedical applications. Modifications and integrations of IONPs with different entities viz. organic polymer, doping with inorganic materials, loading with drug, fluorescent dye, or antibodies make them appropriate for their application in broad spectrum of biomedical fields. This review presents and summarizes the fabrication strategies of multifunctional magnetic nanoparticles based on the modification and surface functionalization of MNP. Multifunctional IONPs based recent advances covering a wide array of applications like biosensing and pathogen detection, magnetic resonance imaging (MRI) and biomarker tracking, magnetofection and gene therapy, hyperthermia and chemotherapy, drug delivery and targeted cell killing, bioimaging and therapeutics, stem cell detection and therapy, tissue engineering and organ transplant, nano-vaccines and immune system activation, microbe targeting and destruction, and COVID19 management are also covered.
ISSN:2666-5239