Toward a molecular microbial blood test for tuberculosis infection
The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervention to reduce the risk of disease progression, such as p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224000596 |
| _version_ | 1797213445358092288 |
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| author | Adrian R. Martineau Shruthi Chandran Winnie Palukani Patricia Garrido Jonathan Mayito Stephen T. Reece Divya Tiwari |
| author_facet | Adrian R. Martineau Shruthi Chandran Winnie Palukani Patricia Garrido Jonathan Mayito Stephen T. Reece Divya Tiwari |
| author_sort | Adrian R. Martineau |
| collection | DOAJ |
| description | The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervention to reduce the risk of disease progression, such as preventive antimicrobial therapy. Implementation of this strategy is limited by the fact that existing tests for Mtb infection, which use immunosensitization to Mtb-specific antigens as a proxy for infection, have low positive predictive value for progression to TB. A blood test that detects Mtb deoxyribonucleic acid (DNA) could allow preventive therapy to be targeted at individuals with microbiological evidence of persistent infection. In this review, we summarize recent advances in the development of molecular microbial blood tests for Mtb infection and discuss potential explanations for discordance between their results and those of immunodiagnostic tests in adults with recent exposure to an infectious index case. We also present a roadmap for further development of molecular microbial blood tests for Mtb infection, and highlight the potential for research in this area to provide novel insights into the biology of Mtb infection and yield new tools to support efforts to control the global TB epidemic. |
| first_indexed | 2024-04-24T10:58:23Z |
| format | Article |
| id | doaj.art-48d7e4be3ee94ec5acd5c8bf9b95e305 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-24T10:58:23Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-48d7e4be3ee94ec5acd5c8bf9b95e3052024-04-12T04:44:24ZengElsevierInternational Journal of Infectious Diseases1201-97122024-04-01141106988Toward a molecular microbial blood test for tuberculosis infectionAdrian R. Martineau0Shruthi Chandran1Winnie Palukani2Patricia Garrido3Jonathan Mayito4Stephen T. Reece5Divya Tiwari6Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United Kingdom; Corresponding author.Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United KingdomCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United KingdomCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United KingdomInfectious Diseases Institute, Makerere University, Kampala, UgandaInfectious Diseases and Vaccines, Kymab, Babraham Research Campus, Cambridge, United KingdomCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, United KingdomThe World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervention to reduce the risk of disease progression, such as preventive antimicrobial therapy. Implementation of this strategy is limited by the fact that existing tests for Mtb infection, which use immunosensitization to Mtb-specific antigens as a proxy for infection, have low positive predictive value for progression to TB. A blood test that detects Mtb deoxyribonucleic acid (DNA) could allow preventive therapy to be targeted at individuals with microbiological evidence of persistent infection. In this review, we summarize recent advances in the development of molecular microbial blood tests for Mtb infection and discuss potential explanations for discordance between their results and those of immunodiagnostic tests in adults with recent exposure to an infectious index case. We also present a roadmap for further development of molecular microbial blood tests for Mtb infection, and highlight the potential for research in this area to provide novel insights into the biology of Mtb infection and yield new tools to support efforts to control the global TB epidemic.http://www.sciencedirect.com/science/article/pii/S1201971224000596Latent tuberculosis infectionMolecular diagnosticsBlood test |
| spellingShingle | Adrian R. Martineau Shruthi Chandran Winnie Palukani Patricia Garrido Jonathan Mayito Stephen T. Reece Divya Tiwari Toward a molecular microbial blood test for tuberculosis infection International Journal of Infectious Diseases Latent tuberculosis infection Molecular diagnostics Blood test |
| title | Toward a molecular microbial blood test for tuberculosis infection |
| title_full | Toward a molecular microbial blood test for tuberculosis infection |
| title_fullStr | Toward a molecular microbial blood test for tuberculosis infection |
| title_full_unstemmed | Toward a molecular microbial blood test for tuberculosis infection |
| title_short | Toward a molecular microbial blood test for tuberculosis infection |
| title_sort | toward a molecular microbial blood test for tuberculosis infection |
| topic | Latent tuberculosis infection Molecular diagnostics Blood test |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224000596 |
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