Filamin-a increases the stability and plasma membrane expression of polycystin-2.

Filamin-a increases the stability and plasma membrane expression of polycystin-2.

Polycystin-2 (PC2), encoded by the PKD2 gene, is mutated in ~15% of autosomal dominant polycystic kidney disease. Filamins are actin-binding proteins implicated in scaffolding and membrane stabilization. Here we studied the effects of filamin on PC2 stability using filamin-deficient human melanoma M...

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Bibliographic Details
Main Authors: Qian Wang, Wang Zheng, Zuocheng Wang, JungWoo Yang, Shaimaa Hussein, Jingfeng Tang, Xing-Zhen Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4393133?pdf=render

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