Separation and purification of curcumin preparation of morphology controlled micro particles
<p>Curcumin was extracted from turmeric plants which is the most commonly used natural pigments, and possess a variety of pharmacological functions except for using pigment. The morphology and particle size of curcumin are main factors affecting the application. Therefore, the morphology and p...
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| Format: | Article |
| Language: | English |
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Mongolian Academy of Sciences
2014-12-01
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| Series: | Mongolian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.mongoliajol.info/index.php/MJC/article/view/314 |
| _version_ | 1811237810922848256 |
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| author | Ts Tsedendorj Hong Hai-long Han Li-min N Lkhagvajav B Darkhijav |
| author_facet | Ts Tsedendorj Hong Hai-long Han Li-min N Lkhagvajav B Darkhijav |
| author_sort | Ts Tsedendorj |
| collection | DOAJ |
| description | <p>Curcumin was extracted from turmeric plants which is the most commonly used natural pigments, and possess a variety of pharmacological functions except for using pigment. The morphology and particle size of curcumin are main factors affecting the application. Therefore, the morphology and particle size distribution of curcumin were effectively controlled by advanced technology, which is significant for expanding the application and added value of curcumin. The curcumin crystal was obtained from curcumin pigments by using column chromatography and recrystallization techniques. The composition and structure of curcumin were characterized by elementary analysis, UV-Vis, IR and NMR. Micronization of curcumin was carried out the Solution Enhanced Dispersion by Supercritical Fluids (SEDS) technology. In the process, supercritical carbon dioxide was used as anti-solvent and acetone/dichloromethane (1:4, v:v) was used as solvent. The curcumin crystals with PSs of about 378 μm were successfully micronized by the SEDS process to micro particles with PSs of about 2.6-10 μm. The acicular, leaves, dendritic and tubular micro particles were obtained through controlling parameters such as pressure, temperature, solution concentration and solution flow rate.</p><p>DOI: <a href="http://doi.dx.org/10.5564/mjc.v15i0.314">http://doi.dx.org/10.5564/mjc.v15i0.314</a></p> <p>Mongolian Journal of Chemistry 15 (41), 2014, p11-14</p> |
| first_indexed | 2024-04-12T12:29:37Z |
| format | Article |
| id | doaj.art-48d8fe55bcca44a2a1a0fd9d55e1168c |
| institution | Directory Open Access Journal |
| issn | 2226-6739 2414-0082 |
| language | English |
| last_indexed | 2024-04-12T12:29:37Z |
| publishDate | 2014-12-01 |
| publisher | Mongolian Academy of Sciences |
| record_format | Article |
| series | Mongolian Journal of Chemistry |
| spelling | doaj.art-48d8fe55bcca44a2a1a0fd9d55e1168c2022-12-22T03:33:03ZengMongolian Academy of SciencesMongolian Journal of Chemistry2226-67392414-00822014-12-01150111410.5564/mjc.v15i0.314314Separation and purification of curcumin preparation of morphology controlled micro particlesTs Tsedendorj0Hong Hai-long1Han Li-min2N Lkhagvajav3B Darkhijav4Institute of Chemistry and Chemical Technology, MASChemical engineering college, Inner Mongolia University of TechnologyChemical engineering college, Inner Mongolia University of TechnologyPlant Protection Research Institute, UlaanbaatarInstitute of Chemistry and Chemical Technology, MAS<p>Curcumin was extracted from turmeric plants which is the most commonly used natural pigments, and possess a variety of pharmacological functions except for using pigment. The morphology and particle size of curcumin are main factors affecting the application. Therefore, the morphology and particle size distribution of curcumin were effectively controlled by advanced technology, which is significant for expanding the application and added value of curcumin. The curcumin crystal was obtained from curcumin pigments by using column chromatography and recrystallization techniques. The composition and structure of curcumin were characterized by elementary analysis, UV-Vis, IR and NMR. Micronization of curcumin was carried out the Solution Enhanced Dispersion by Supercritical Fluids (SEDS) technology. In the process, supercritical carbon dioxide was used as anti-solvent and acetone/dichloromethane (1:4, v:v) was used as solvent. The curcumin crystals with PSs of about 378 μm were successfully micronized by the SEDS process to micro particles with PSs of about 2.6-10 μm. The acicular, leaves, dendritic and tubular micro particles were obtained through controlling parameters such as pressure, temperature, solution concentration and solution flow rate.</p><p>DOI: <a href="http://doi.dx.org/10.5564/mjc.v15i0.314">http://doi.dx.org/10.5564/mjc.v15i0.314</a></p> <p>Mongolian Journal of Chemistry 15 (41), 2014, p11-14</p>http://www.mongoliajol.info/index.php/MJC/article/view/314CurcuminSupercritical fluidMicro particleMorphology |
| spellingShingle | Ts Tsedendorj Hong Hai-long Han Li-min N Lkhagvajav B Darkhijav Separation and purification of curcumin preparation of morphology controlled micro particles Mongolian Journal of Chemistry Curcumin Supercritical fluid Micro particle Morphology |
| title | Separation and purification of curcumin preparation of morphology controlled micro particles |
| title_full | Separation and purification of curcumin preparation of morphology controlled micro particles |
| title_fullStr | Separation and purification of curcumin preparation of morphology controlled micro particles |
| title_full_unstemmed | Separation and purification of curcumin preparation of morphology controlled micro particles |
| title_short | Separation and purification of curcumin preparation of morphology controlled micro particles |
| title_sort | separation and purification of curcumin preparation of morphology controlled micro particles |
| topic | Curcumin Supercritical fluid Micro particle Morphology |
| url | http://www.mongoliajol.info/index.php/MJC/article/view/314 |
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