C/EBPβ Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes

C/EBPβ Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes

Human embryonic stem cells (hESCs) hold the potential to solve the problem of the shortage of functional hepatocytes in clinical applications and drug development. However, a large number of usable hepatocytes derived from hESCs cannot be effectively obtained due to the limited proliferation capacit...

Full description

Bibliographic Details
Main Authors: Shoupei Liu, Jue Wang, Sen Chen, Zonglin Han, Haibin Wu, Honglin Chen, Yuyou Duan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
human embryonic stem cells
liver enriched transcription factor
C/EBPβ
E2F
hepatocyte differentiation
cell cycle
Online Access:https://www.mdpi.com/2073-4409/12/3/497

Similar Items

Similar Items