Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy

Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy

Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse events. Thus, the development of improved drug delivery systems that can sense and respond commensurately to disease flares represents an unmet...

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Bibliographic Details
Main Authors: Kelsey H. Collins, Lara Pferdehirt, Leila S. Saleh, Alireza Savadipour, Luke E. Springer, Kristin L. Lenz, Dominic M. Thompson, Sara J. Oswald, Christine T. N. Pham, Farshid Guilak
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Gels
Subjects:
induced pluripotent stem cells
implant
drug delivery
rheumatoid arthritis
autoimmune
designer cells
Online Access:https://www.mdpi.com/2310-2861/9/2/169

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