Experimental skin carcinoma by UVB application
OBJECTIVES AND BACKGROUND The aim of this research study was to evaluate the harmful effects at skin level induced by concomitant and repeated exposure to three toxic agents: UVB radiation, DMBA and TPA. MATERIALS AND METHODS Experimental mice were divided in thw following groups (n=5 mice/gr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/41/article_41.pdf |
| Summary: | OBJECTIVES AND BACKGROUND
The aim of this research study was to evaluate the
harmful effects at skin level induced by concomitant and
repeated exposure to three toxic agents: UVB radiation,
DMBA and TPA.
MATERIALS AND METHODS
Experimental mice were divided in thw following
groups (n=5 mice/group): group 1 – healthy mice, group
2 – mice exposed to UVB – radiation and topical
administration of acetone and group 3 – mice exposed to
UVB – radiation and topical application of DMBA and
TPA solutions (phase I - double tumor initiation and
phase II - tumor promotion).
RESULTS
Application of these compounds led to the
development of skin papilloma and to significant changes
in skin parameters.
CONCLUSIONS
The barrier function of the skin was degraded in
UVB exposed mice. DMBA and TPA depended on
carcinogens schedule and corelated with skin carcinoma.
Graphical abstract: Schematic protocol of
experimental skin carcinoma
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| ISSN: | 2360-1124 2537-5393 |