Experimental skin carcinoma by UVB application
OBJECTIVES AND BACKGROUND The aim of this research study was to evaluate the harmful effects at skin level induced by concomitant and repeated exposure to three toxic agents: UVB radiation, DMBA and TPA. MATERIALS AND METHODS Experimental mice were divided in thw following groups (n=5 mice/gr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/41/article_41.pdf |
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| author | Andrada Iftode Mircea Florin Berceanu Raul Chioibas Andrei Motoc Zorin Crainiceanu Tiberiu Bratu Dorina Coricovac Iulia Pinzaru Ioana Zinuca Pavel |
| author_facet | Andrada Iftode Mircea Florin Berceanu Raul Chioibas Andrei Motoc Zorin Crainiceanu Tiberiu Bratu Dorina Coricovac Iulia Pinzaru Ioana Zinuca Pavel |
| author_sort | Andrada Iftode |
| collection | DOAJ |
| description | OBJECTIVES AND BACKGROUND
The aim of this research study was to evaluate the
harmful effects at skin level induced by concomitant and
repeated exposure to three toxic agents: UVB radiation,
DMBA and TPA.
MATERIALS AND METHODS
Experimental mice were divided in thw following
groups (n=5 mice/group): group 1 – healthy mice, group
2 – mice exposed to UVB – radiation and topical
administration of acetone and group 3 – mice exposed to
UVB – radiation and topical application of DMBA and
TPA solutions (phase I - double tumor initiation and
phase II - tumor promotion).
RESULTS
Application of these compounds led to the
development of skin papilloma and to significant changes
in skin parameters.
CONCLUSIONS
The barrier function of the skin was degraded in
UVB exposed mice. DMBA and TPA depended on
carcinogens schedule and corelated with skin carcinoma.
Graphical abstract: Schematic protocol of
experimental skin carcinoma
REFERENCES
1. Lee Ja, Ko Jh, Jung Bg, Kim Th, Hong Ji,
Park Ys, Lee Bj. Fermented Prunus mume
with Probiotics Inhibits 7,12-
Dimethylbenz[a]anthracene and 12-OTetradecanoyl
phorbol-13-acetate Induced
Skin Carcinogenesis through Alleviation of
Oxidative Stress. Asian Pac J Cancer Prev.
2013;14:2973-2978.
2. Firooz A, Sadr B, Babakoohi S, Sarraf-Yazdy
M, Fanian F, Kazerouni-Timsar A, NassiriKashani
M, Naghizadeh MM, Dowlati Y.
Variation of Biophysical Parameters of the
Skin with Age, Gender, and Body Region.
Scientific World Journal. 2012;
doi.org/10.1100/2012/386936
3. Gheorgheosu (Coricovac) D, Borcan F,
Balasz NI, Soica C, Simu G, Kemeny L,
Dehelean CA. Evaluation of skin
parameters in C57BL/6J mice exposed to
chemical and environmental factors using
non-invasive methods. J Agroalim Proc
Technol. 2014;20:14-20. |
| first_indexed | 2024-12-23T02:16:08Z |
| format | Article |
| id | doaj.art-48dcd82192a04df39cdea77183ad5411 |
| institution | Directory Open Access Journal |
| issn | 2360-1124 2537-5393 |
| language | English |
| last_indexed | 2024-12-23T02:16:08Z |
| publishDate | 2016-12-01 |
| publisher | Victor Babes University of Medicine and Pharmacy Timisoara |
| record_format | Article |
| series | Research and Clinical Medicine |
| spelling | doaj.art-48dcd82192a04df39cdea77183ad54112022-12-21T18:03:40ZengVictor Babes University of Medicine and Pharmacy TimisoaraResearch and Clinical Medicine2360-11242537-53932016-12-01ISuppl.12020Experimental skin carcinoma by UVB applicationAndrada Iftode0Mircea Florin Berceanu1Raul Chioibas2Andrei Motoc3Zorin Crainiceanu4Tiberiu Bratu5Dorina Coricovac6Iulia Pinzaru7Ioana Zinuca Pavel8. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. MEDCOM Clinic CBS Hospital Timișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, Romania. Victor Babeș University of Medicine and PharmacyTimișoara, RomaniaOBJECTIVES AND BACKGROUND The aim of this research study was to evaluate the harmful effects at skin level induced by concomitant and repeated exposure to three toxic agents: UVB radiation, DMBA and TPA. MATERIALS AND METHODS Experimental mice were divided in thw following groups (n=5 mice/group): group 1 – healthy mice, group 2 – mice exposed to UVB – radiation and topical administration of acetone and group 3 – mice exposed to UVB – radiation and topical application of DMBA and TPA solutions (phase I - double tumor initiation and phase II - tumor promotion). RESULTS Application of these compounds led to the development of skin papilloma and to significant changes in skin parameters. CONCLUSIONS The barrier function of the skin was degraded in UVB exposed mice. DMBA and TPA depended on carcinogens schedule and corelated with skin carcinoma. Graphical abstract: Schematic protocol of experimental skin carcinoma REFERENCES 1. Lee Ja, Ko Jh, Jung Bg, Kim Th, Hong Ji, Park Ys, Lee Bj. Fermented Prunus mume with Probiotics Inhibits 7,12- Dimethylbenz[a]anthracene and 12-OTetradecanoyl phorbol-13-acetate Induced Skin Carcinogenesis through Alleviation of Oxidative Stress. Asian Pac J Cancer Prev. 2013;14:2973-2978. 2. Firooz A, Sadr B, Babakoohi S, Sarraf-Yazdy M, Fanian F, Kazerouni-Timsar A, NassiriKashani M, Naghizadeh MM, Dowlati Y. Variation of Biophysical Parameters of the Skin with Age, Gender, and Body Region. Scientific World Journal. 2012; doi.org/10.1100/2012/386936 3. Gheorgheosu (Coricovac) D, Borcan F, Balasz NI, Soica C, Simu G, Kemeny L, Dehelean CA. Evaluation of skin parameters in C57BL/6J mice exposed to chemical and environmental factors using non-invasive methods. J Agroalim Proc Technol. 2014;20:14-20.http://www.resclinmed.eu/public/data_files/articles/41/article_41.pdfUVBskin carcinomaparameters. |
| spellingShingle | Andrada Iftode Mircea Florin Berceanu Raul Chioibas Andrei Motoc Zorin Crainiceanu Tiberiu Bratu Dorina Coricovac Iulia Pinzaru Ioana Zinuca Pavel Experimental skin carcinoma by UVB application Research and Clinical Medicine UVB skin carcinoma parameters. |
| title | Experimental skin carcinoma by UVB application |
| title_full | Experimental skin carcinoma by UVB application |
| title_fullStr | Experimental skin carcinoma by UVB application |
| title_full_unstemmed | Experimental skin carcinoma by UVB application |
| title_short | Experimental skin carcinoma by UVB application |
| title_sort | experimental skin carcinoma by uvb application |
| topic | UVB skin carcinoma parameters. |
| url | http://www.resclinmed.eu/public/data_files/articles/41/article_41.pdf |
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