Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins
Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation fr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Journal of Ginseng Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845318302495 |
| _version_ | 1828297966788542464 |
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| author | Chaoming Wang Juan Liu Jianqiang Deng Jiazhen Wang Weizhao Weng Hongxia Chu Qingguo Meng |
| author_facet | Chaoming Wang Juan Liu Jianqiang Deng Jiazhen Wang Weizhao Weng Hongxia Chu Qingguo Meng |
| author_sort | Chaoming Wang |
| collection | DOAJ |
| description | Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by 13C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized. Keywords: 20(R)-ginseng saponin, Epimerization, Identification, Metabolism, Pharmacological activity |
| first_indexed | 2024-04-13T12:33:28Z |
| format | Article |
| id | doaj.art-48dce923dc1d4d80826b067d68c597c7 |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-04-13T12:33:28Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-48dce923dc1d4d80826b067d68c597c72022-12-22T02:46:43ZengElsevierJournal of Ginseng Research1226-84532020-01-014411423Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponinsChaoming Wang0Juan Liu1Jianqiang Deng2Jiazhen Wang3Weizhao Weng4Hongxia Chu5Qingguo Meng6School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, ChinaDepartment of Cardiovascular Medicine, Yuhuangding Hospital of Yantai, Shandong, ChinaSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China; Corresponding author. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China.Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by 13C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized. Keywords: 20(R)-ginseng saponin, Epimerization, Identification, Metabolism, Pharmacological activityhttp://www.sciencedirect.com/science/article/pii/S1226845318302495 |
| spellingShingle | Chaoming Wang Juan Liu Jianqiang Deng Jiazhen Wang Weizhao Weng Hongxia Chu Qingguo Meng Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins Journal of Ginseng Research |
| title | Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins |
| title_full | Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins |
| title_fullStr | Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins |
| title_full_unstemmed | Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins |
| title_short | Advances in the chemistry, pharmacological diversity, and metabolism of 20(R)-ginseng saponins |
| title_sort | advances in the chemistry pharmacological diversity and metabolism of 20 r ginseng saponins |
| url | http://www.sciencedirect.com/science/article/pii/S1226845318302495 |
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