The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients
Background: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTRs). Objectives:...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2016-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/JNP-5-98.pdf |
| _version_ | 1797827969807286272 |
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| author | Ali Monfared Seyyede Zeinab Azimi Ehsan Kazemnezhad |
| author_facet | Ali Monfared Seyyede Zeinab Azimi Ehsan Kazemnezhad |
| author_sort | Ali Monfared |
| collection | DOAJ |
| description | Background: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTRs). Objectives: The objective of our study was to evaluate the association between atorvastatin administration and plasma total homocysteine (tHcy) levels in RTRs. Patients and Methods: We performed a retrospective cross-sectional study in 148 cyclosporine A (CsA) treated stable RTRs. We compared tHcy level and other demographic and clinical variables in RTRs with and without atorvastatin. Results: 58.1% of the 148 RTRs were treated with atorvastatin (20-40 mg/day). Mean tHcy levels were lower in patients treated with atorvastatin compared to nonusers (14.80 ± 5.13 µmol/l versus 16.95 ± 7.87 µmol/l, P = 0.04). The comparison of 85 patients treated with atorvastatin and 61 non-users revealed that those subjects with atorvastatin were older, with higher estimated creatinine clearance and elevated body mass index (BMI). They were more likely to have higher systolic blood pressure and CsA trough level (C0). The association between lower tHcy levels and atorvastatin use was confirmed in the multivariate regression model (P = 0.004). However tHcy levels were independently and negatively associated with serum folate (P = 0.0001) and vitamin B12 levels (P = 0.001) and positively with serum BUN (P = 0.001) and diastolic blood pressure (P = 0.024) as well. Conclusions: These data support the association between lower tHcy levels and atorvastatin administration in RTRs. Further clinical trials are recommended to clarify homocysteine lowering effect of atorvastatin. |
| first_indexed | 2024-04-09T12:56:57Z |
| format | Article |
| id | doaj.art-48dd3f198dee4b42888a637a464d8573 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:56:57Z |
| publishDate | 2016-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-48dd3f198dee4b42888a637a464d85732023-05-13T11:32:52ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192016-07-01539810410.15171/jnp.2016.18JNP_20160708150403The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipientsAli Monfared0Seyyede Zeinab Azimi1Ehsan Kazemnezhad2Urology Research Center, Guilan University of Medical Sciences, Guilan, IranUrology Research Center, Guilan University of Medical Sciences, Guilan, IranUrology Research Center, Guilan University of Medical Sciences, Guilan, IranBackground: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTRs). Objectives: The objective of our study was to evaluate the association between atorvastatin administration and plasma total homocysteine (tHcy) levels in RTRs. Patients and Methods: We performed a retrospective cross-sectional study in 148 cyclosporine A (CsA) treated stable RTRs. We compared tHcy level and other demographic and clinical variables in RTRs with and without atorvastatin. Results: 58.1% of the 148 RTRs were treated with atorvastatin (20-40 mg/day). Mean tHcy levels were lower in patients treated with atorvastatin compared to nonusers (14.80 ± 5.13 µmol/l versus 16.95 ± 7.87 µmol/l, P = 0.04). The comparison of 85 patients treated with atorvastatin and 61 non-users revealed that those subjects with atorvastatin were older, with higher estimated creatinine clearance and elevated body mass index (BMI). They were more likely to have higher systolic blood pressure and CsA trough level (C0). The association between lower tHcy levels and atorvastatin use was confirmed in the multivariate regression model (P = 0.004). However tHcy levels were independently and negatively associated with serum folate (P = 0.0001) and vitamin B12 levels (P = 0.001) and positively with serum BUN (P = 0.001) and diastolic blood pressure (P = 0.024) as well. Conclusions: These data support the association between lower tHcy levels and atorvastatin administration in RTRs. Further clinical trials are recommended to clarify homocysteine lowering effect of atorvastatin.https://nephropathol.com/PDF/JNP-5-98.pdfhomocysteineatorvastatintransplantationrenaltransplant recipients |
| spellingShingle | Ali Monfared Seyyede Zeinab Azimi Ehsan Kazemnezhad The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients Journal of Nephropathology homocysteine atorvastatin transplantation renal transplant recipients |
| title | The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| title_full | The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| title_fullStr | The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| title_full_unstemmed | The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| title_short | The association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| title_sort | association between atorvastatin administration and plasma total homocysteine levels in renal transplant recipients |
| topic | homocysteine atorvastatin transplantation renal transplant recipients |
| url | https://nephropathol.com/PDF/JNP-5-98.pdf |
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