Toxoplasmosis in Transplant Recipients, Europe, 2010–2014
Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Euro...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2018-08-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/8/18-0045_article |
| _version_ | 1818446589231890432 |
|---|---|
| author | Florence Robert-Gangneux Valeria Meroni Damien Dupont Françoise Botterel José M. Aguado Garcia Marie-Pierre Brenier-Pinchart Isabelle Accoceberry Hamdi Akan Isabella Abbate Katia Boggian Fabrizio Bruschi Jordi Carratalà Miruna David Lubos Drgona Olgica Djurković-Djaković Maria Carmen Farinas Francesca Genco Effrossyni Gkrania-Klotsas Andreas H. Groll Edward Guy Cédric Hirzel Nina Khanna Özgür Kurt Lia Monica Junie Tiziana Lazzarotto Oscar Len Nicolas J. Mueller Patricia Munoz Zoi Dorothea Pana Emmanuel Roilides Tijana Stajner Christian van Delden Isabelle Villena Hervé Pelloux Oriol Manuel |
| author_facet | Florence Robert-Gangneux Valeria Meroni Damien Dupont Françoise Botterel José M. Aguado Garcia Marie-Pierre Brenier-Pinchart Isabelle Accoceberry Hamdi Akan Isabella Abbate Katia Boggian Fabrizio Bruschi Jordi Carratalà Miruna David Lubos Drgona Olgica Djurković-Djaković Maria Carmen Farinas Francesca Genco Effrossyni Gkrania-Klotsas Andreas H. Groll Edward Guy Cédric Hirzel Nina Khanna Özgür Kurt Lia Monica Junie Tiziana Lazzarotto Oscar Len Nicolas J. Mueller Patricia Munoz Zoi Dorothea Pana Emmanuel Roilides Tijana Stajner Christian van Delden Isabelle Villena Hervé Pelloux Oriol Manuel |
| author_sort | Florence Robert-Gangneux |
| collection | DOAJ |
| description | Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010–2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management. |
| first_indexed | 2024-12-14T19:50:07Z |
| format | Article |
| id | doaj.art-48df254cf5314a0aafcdd203224de6df |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T19:50:07Z |
| publishDate | 2018-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-48df254cf5314a0aafcdd203224de6df2022-12-21T22:49:27ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-08-012481497150410.3201/eid2408.180045Toxoplasmosis in Transplant Recipients, Europe, 2010–2014Florence Robert-GangneuxValeria MeroniDamien DupontFrançoise BotterelJosé M. Aguado GarciaMarie-Pierre Brenier-PinchartIsabelle AccoceberryHamdi AkanIsabella AbbateKatia BoggianFabrizio BruschiJordi CarratalàMiruna DavidLubos DrgonaOlgica Djurković-DjakovićMaria Carmen FarinasFrancesca GencoEffrossyni Gkrania-KlotsasAndreas H. GrollEdward GuyCédric HirzelNina KhannaÖzgür KurtLia Monica JunieTiziana LazzarottoOscar LenNicolas J. MuellerPatricia MunozZoi Dorothea PanaEmmanuel RoilidesTijana StajnerChristian van DeldenIsabelle VillenaHervé PellouxOriol ManuelTransplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010–2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.https://wwwnc.cdc.gov/eid/article/24/8/18-0045_articletoxoplasma infectiontransplantationtransplant recipientcerebral toxoplasmosishematopoietic stem cell transplantchemoprophylaxis |
| spellingShingle | Florence Robert-Gangneux Valeria Meroni Damien Dupont Françoise Botterel José M. Aguado Garcia Marie-Pierre Brenier-Pinchart Isabelle Accoceberry Hamdi Akan Isabella Abbate Katia Boggian Fabrizio Bruschi Jordi Carratalà Miruna David Lubos Drgona Olgica Djurković-Djaković Maria Carmen Farinas Francesca Genco Effrossyni Gkrania-Klotsas Andreas H. Groll Edward Guy Cédric Hirzel Nina Khanna Özgür Kurt Lia Monica Junie Tiziana Lazzarotto Oscar Len Nicolas J. Mueller Patricia Munoz Zoi Dorothea Pana Emmanuel Roilides Tijana Stajner Christian van Delden Isabelle Villena Hervé Pelloux Oriol Manuel Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 Emerging Infectious Diseases toxoplasma infection transplantation transplant recipient cerebral toxoplasmosis hematopoietic stem cell transplant chemoprophylaxis |
| title | Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 |
| title_full | Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 |
| title_fullStr | Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 |
| title_full_unstemmed | Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 |
| title_short | Toxoplasmosis in Transplant Recipients, Europe, 2010–2014 |
| title_sort | toxoplasmosis in transplant recipients europe 2010 2014 |
| topic | toxoplasma infection transplantation transplant recipient cerebral toxoplasmosis hematopoietic stem cell transplant chemoprophylaxis |
| url | https://wwwnc.cdc.gov/eid/article/24/8/18-0045_article |
| work_keys_str_mv | AT florencerobertgangneux toxoplasmosisintransplantrecipientseurope20102014 AT valeriameroni toxoplasmosisintransplantrecipientseurope20102014 AT damiendupont toxoplasmosisintransplantrecipientseurope20102014 AT francoisebotterel toxoplasmosisintransplantrecipientseurope20102014 AT josemaguadogarcia toxoplasmosisintransplantrecipientseurope20102014 AT mariepierrebrenierpinchart toxoplasmosisintransplantrecipientseurope20102014 AT isabelleaccoceberry toxoplasmosisintransplantrecipientseurope20102014 AT hamdiakan toxoplasmosisintransplantrecipientseurope20102014 AT isabellaabbate toxoplasmosisintransplantrecipientseurope20102014 AT katiaboggian toxoplasmosisintransplantrecipientseurope20102014 AT fabriziobruschi toxoplasmosisintransplantrecipientseurope20102014 AT jordicarratala toxoplasmosisintransplantrecipientseurope20102014 AT mirunadavid toxoplasmosisintransplantrecipientseurope20102014 AT lubosdrgona toxoplasmosisintransplantrecipientseurope20102014 AT olgicadjurkovicdjakovic toxoplasmosisintransplantrecipientseurope20102014 AT mariacarmenfarinas toxoplasmosisintransplantrecipientseurope20102014 AT francescagenco toxoplasmosisintransplantrecipientseurope20102014 AT effrossynigkraniaklotsas toxoplasmosisintransplantrecipientseurope20102014 AT andreashgroll toxoplasmosisintransplantrecipientseurope20102014 AT edwardguy toxoplasmosisintransplantrecipientseurope20102014 AT cedrichirzel toxoplasmosisintransplantrecipientseurope20102014 AT ninakhanna toxoplasmosisintransplantrecipientseurope20102014 AT ozgurkurt toxoplasmosisintransplantrecipientseurope20102014 AT liamonicajunie toxoplasmosisintransplantrecipientseurope20102014 AT tizianalazzarotto toxoplasmosisintransplantrecipientseurope20102014 AT oscarlen toxoplasmosisintransplantrecipientseurope20102014 AT nicolasjmueller toxoplasmosisintransplantrecipientseurope20102014 AT patriciamunoz toxoplasmosisintransplantrecipientseurope20102014 AT zoidorotheapana toxoplasmosisintransplantrecipientseurope20102014 AT emmanuelroilides toxoplasmosisintransplantrecipientseurope20102014 AT tijanastajner toxoplasmosisintransplantrecipientseurope20102014 AT christianvandelden toxoplasmosisintransplantrecipientseurope20102014 AT isabellevillena toxoplasmosisintransplantrecipientseurope20102014 AT hervepelloux toxoplasmosisintransplantrecipientseurope20102014 AT oriolmanuel toxoplasmosisintransplantrecipientseurope20102014 |