Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives
David G Ingram,1 Jill M Arganbright,2 Emily Paprocki,3 Kelsee L Halpin3 1Division of Pulmonary and Sleep Medicine, Children’s Mercy Hospital, Kansas City, MO, USA; 2Division of Pediatric Otolaryngology, Children’s Mercy Hospital, Kansas City, MO, USA; 3Division of Pediatric Endocrinology, Children’s...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/sleep-disorders-in-children-with-prader-willi-syndrome-current-perspec-peer-reviewed-fulltext-article-NSS |
| _version_ | 1811233412702273536 |
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| author | Ingram DG Arganbright JM Paprocki E Halpin KL |
| author_facet | Ingram DG Arganbright JM Paprocki E Halpin KL |
| author_sort | Ingram DG |
| collection | DOAJ |
| description | David G Ingram,1 Jill M Arganbright,2 Emily Paprocki,3 Kelsee L Halpin3 1Division of Pulmonary and Sleep Medicine, Children’s Mercy Hospital, Kansas City, MO, USA; 2Division of Pediatric Otolaryngology, Children’s Mercy Hospital, Kansas City, MO, USA; 3Division of Pediatric Endocrinology, Children’s Mercy Hospital, Kansas City, MO, USACorrespondence: David G Ingram, Division of Pulmonary and Sleep Medicine, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA, Tel +1 816-983-6490, Email dgingram@cmh.eduAbstract: Children with Prader-Willi syndrome (PWS) face a multitude of potential health challenges including life-threatening obesity, endocrinopathies, behavioral and emotional dysregulation, developmental delays, and sleep disorders. In the current perspective piece, we provide a focused review of the condition’s etiology and clinical findings, as well as a more in-depth discussion of sleep disorders frequently associated with PWS. In particular, we highlight and discuss difficult clinical scenarios frequently encountered by the pediatric sleep physician caring for this patient population, including diagnosis and treatment of complex sleep-related breathing disorders, considerations for sleep apnea surgery, the interplay between growth hormone and sleep apnea, diagnostic challenges in hypersomnia/narcolepsy, and current and emerging therapies for hypersomnia/narcolepsy. Overall, although there are many areas that need further research, sleep disorders remain a fruitful target for improving quality of life of children with PWS and their families.Keywords: Prader-Willi syndrome, narcolepsy, growth hormone, sleep apnea |
| first_indexed | 2024-04-12T11:18:56Z |
| format | Article |
| id | doaj.art-48e09f490d8c4327951043e2a8cf6c58 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-04-12T11:18:56Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-48e09f490d8c4327951043e2a8cf6c582022-12-22T03:35:25ZengDove Medical PressNature and Science of Sleep1179-16082022-11-01Volume 142065207479587Sleep Disorders in Children with Prader Willi Syndrome: Current PerspectivesIngram DGArganbright JMPaprocki EHalpin KLDavid G Ingram,1 Jill M Arganbright,2 Emily Paprocki,3 Kelsee L Halpin3 1Division of Pulmonary and Sleep Medicine, Children’s Mercy Hospital, Kansas City, MO, USA; 2Division of Pediatric Otolaryngology, Children’s Mercy Hospital, Kansas City, MO, USA; 3Division of Pediatric Endocrinology, Children’s Mercy Hospital, Kansas City, MO, USACorrespondence: David G Ingram, Division of Pulmonary and Sleep Medicine, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA, Tel +1 816-983-6490, Email dgingram@cmh.eduAbstract: Children with Prader-Willi syndrome (PWS) face a multitude of potential health challenges including life-threatening obesity, endocrinopathies, behavioral and emotional dysregulation, developmental delays, and sleep disorders. In the current perspective piece, we provide a focused review of the condition’s etiology and clinical findings, as well as a more in-depth discussion of sleep disorders frequently associated with PWS. In particular, we highlight and discuss difficult clinical scenarios frequently encountered by the pediatric sleep physician caring for this patient population, including diagnosis and treatment of complex sleep-related breathing disorders, considerations for sleep apnea surgery, the interplay between growth hormone and sleep apnea, diagnostic challenges in hypersomnia/narcolepsy, and current and emerging therapies for hypersomnia/narcolepsy. Overall, although there are many areas that need further research, sleep disorders remain a fruitful target for improving quality of life of children with PWS and their families.Keywords: Prader-Willi syndrome, narcolepsy, growth hormone, sleep apneahttps://www.dovepress.com/sleep-disorders-in-children-with-prader-willi-syndrome-current-perspec-peer-reviewed-fulltext-article-NSSprader-willi syndromenarcolepsygrowth hormonesleep apnea. |
| spellingShingle | Ingram DG Arganbright JM Paprocki E Halpin KL Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives Nature and Science of Sleep prader-willi syndrome narcolepsy growth hormone sleep apnea. |
| title | Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives |
| title_full | Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives |
| title_fullStr | Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives |
| title_full_unstemmed | Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives |
| title_short | Sleep Disorders in Children with Prader Willi Syndrome: Current Perspectives |
| title_sort | sleep disorders in children with prader willi syndrome current perspectives |
| topic | prader-willi syndrome narcolepsy growth hormone sleep apnea. |
| url | https://www.dovepress.com/sleep-disorders-in-children-with-prader-willi-syndrome-current-perspec-peer-reviewed-fulltext-article-NSS |
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