Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice
Osteoporosis is a common skeletal disease in which bone resorption exceeds bone formation. Intestinal health has been linked to reduced osteoporosis. The aim of this study was to compare the anti-osteoporotic and intestinal health effects of two strains of Lactobacillus plantarum (AR237 and AR495) i...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621004114 |
| _version_ | 1818400461278937088 |
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| author | Jing Yu Yongjun Xia Guangqiang Wang Zhiqiang Xiong Hui Zhang Phoency F.-H. Lai Xin Song Lianzhong Ai |
| author_facet | Jing Yu Yongjun Xia Guangqiang Wang Zhiqiang Xiong Hui Zhang Phoency F.-H. Lai Xin Song Lianzhong Ai |
| author_sort | Jing Yu |
| collection | DOAJ |
| description | Osteoporosis is a common skeletal disease in which bone resorption exceeds bone formation. Intestinal health has been linked to reduced osteoporosis. The aim of this study was to compare the anti-osteoporotic and intestinal health effects of two strains of Lactobacillus plantarum (AR237 and AR495) in ovariectomized (ovx) C57BL/6 mice. The results showed that AR495 significantly inhibited ovx-induced bone loss, reduced intestinal permeability, increased the expression of tight junction proteins, claudin-family proteins, zonula occludens-1 (ZO-1), and junctional adhesion molecule 3 (JAM-3) in ovx mice. Furthermore, AR495 inhibited bone resorption by modulating the receptor activator for nuclear factor kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, and ameliorated ovx-induced intestinal inflammatory responses. AR495 improved intestinal microbial stability, and increased the abundance of short-chain fatty acids (SCFA)-producing bacteria and fecal SCFA content of ovx mice. Overall, the findings of this study showed that AR495 was more effective than AR237 at treating osteoporosis. |
| first_indexed | 2024-12-14T07:36:56Z |
| format | Article |
| id | doaj.art-48e199f6bd3443dab6512a2d5c256b8c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T07:36:56Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-48e199f6bd3443dab6512a2d5c256b8c2022-12-21T23:11:10ZengElsevierJournal of Functional Foods1756-46462021-12-0187104762Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized miceJing Yu0Yongjun Xia1Guangqiang Wang2Zhiqiang Xiong3Hui Zhang4Phoency F.-H. Lai5Xin Song6Lianzhong Ai7School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaCorresponding author.; School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaOsteoporosis is a common skeletal disease in which bone resorption exceeds bone formation. Intestinal health has been linked to reduced osteoporosis. The aim of this study was to compare the anti-osteoporotic and intestinal health effects of two strains of Lactobacillus plantarum (AR237 and AR495) in ovariectomized (ovx) C57BL/6 mice. The results showed that AR495 significantly inhibited ovx-induced bone loss, reduced intestinal permeability, increased the expression of tight junction proteins, claudin-family proteins, zonula occludens-1 (ZO-1), and junctional adhesion molecule 3 (JAM-3) in ovx mice. Furthermore, AR495 inhibited bone resorption by modulating the receptor activator for nuclear factor kappa B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, and ameliorated ovx-induced intestinal inflammatory responses. AR495 improved intestinal microbial stability, and increased the abundance of short-chain fatty acids (SCFA)-producing bacteria and fecal SCFA content of ovx mice. Overall, the findings of this study showed that AR495 was more effective than AR237 at treating osteoporosis.http://www.sciencedirect.com/science/article/pii/S1756464621004114OsteoporosisLactobacillus plantarumIntestinal microbiotaPro-osteoclastogenic signalingSCFA-producing bacteria |
| spellingShingle | Jing Yu Yongjun Xia Guangqiang Wang Zhiqiang Xiong Hui Zhang Phoency F.-H. Lai Xin Song Lianzhong Ai Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice Journal of Functional Foods Osteoporosis Lactobacillus plantarum Intestinal microbiota Pro-osteoclastogenic signaling SCFA-producing bacteria |
| title | Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice |
| title_full | Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice |
| title_fullStr | Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice |
| title_full_unstemmed | Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice |
| title_short | Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice |
| title_sort | anti osteoporotic potential of lactobacillus plantarum ar237 and ar495 in ovariectomized mice |
| topic | Osteoporosis Lactobacillus plantarum Intestinal microbiota Pro-osteoclastogenic signaling SCFA-producing bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621004114 |
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