Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds
Abstract Species from genus Artemisia are widely distributed throughout temperate regions of the northern hemisphere and many cultures have a long-standing traditional use of these plants as herbal remedies, liquors, cosmetics, spices, etc. Nowadays, the discovery of new plant-derived products to be...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55128-z |
| _version_ | 1797274713042452480 |
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| author | Stefano Negri Fabio Pietrolucci Sebastiano Andreatta Ruth Chinyere Njoku Carolina Antunes Silva Nogueira Ramos Massimo Crimi Mauro Commisso Flavia Guzzo Linda Avesani |
| author_facet | Stefano Negri Fabio Pietrolucci Sebastiano Andreatta Ruth Chinyere Njoku Carolina Antunes Silva Nogueira Ramos Massimo Crimi Mauro Commisso Flavia Guzzo Linda Avesani |
| author_sort | Stefano Negri |
| collection | DOAJ |
| description | Abstract Species from genus Artemisia are widely distributed throughout temperate regions of the northern hemisphere and many cultures have a long-standing traditional use of these plants as herbal remedies, liquors, cosmetics, spices, etc. Nowadays, the discovery of new plant-derived products to be used as food supplements or drugs has been pushed by the exploitation of bioprospection approaches. Often driven by the knowledge derived from the ethnobotanical use of plants, bioprospection explores the existing biodiversity through integration of modern omics techniques with targeted bioactivity assays. In this work we set up a bioprospection plan to investigate the phytochemical diversity and the potential bioactivity of five Artemisia species with recognized ethnobotanical tradition (A. absinthium, A. alba, A. annua, A. verlotiorum and A. vulgaris), growing wild in the natural areas of the Verona province. We characterized the specialized metabolomes of the species (including sesquiterpenoids from the artemisinin biosynthesis pathway) through an LC–MS based untargeted approach and, in order to identify potential bioactive metabolites, we correlated their composition with the in vitro antioxidant activity. We propose as potential bioactive compounds several isomers of caffeoyl and feruloyl quinic acid esters (e.g. dicaffeoylquinic acids, feruloylquinic acids and caffeoylferuloylquinic acids), which strongly characterize the most antioxidant species A. verlotiorum and A. annua. Morevoer, in this study we report for the first time the occurrence of sesquiterpenoids from the artemisinin biosynthesis pathway in the species A. alba. |
| first_indexed | 2024-03-07T15:03:13Z |
| format | Article |
| id | doaj.art-48e27ad2c1fd429893dcb8916d9f697e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:13Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-48e27ad2c1fd429893dcb8916d9f697e2024-03-05T19:02:24ZengNature PortfolioScientific Reports2045-23222024-02-0114112110.1038/s41598-024-55128-zBioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compoundsStefano Negri0Fabio Pietrolucci1Sebastiano Andreatta2Ruth Chinyere Njoku3Carolina Antunes Silva Nogueira Ramos4Massimo Crimi5Mauro Commisso6Flavia Guzzo7Linda Avesani8Department of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaMuseo di Storia Naturale, Comune di VeronaDepartment of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaDepartment of Biotechnology, University of VeronaAbstract Species from genus Artemisia are widely distributed throughout temperate regions of the northern hemisphere and many cultures have a long-standing traditional use of these plants as herbal remedies, liquors, cosmetics, spices, etc. Nowadays, the discovery of new plant-derived products to be used as food supplements or drugs has been pushed by the exploitation of bioprospection approaches. Often driven by the knowledge derived from the ethnobotanical use of plants, bioprospection explores the existing biodiversity through integration of modern omics techniques with targeted bioactivity assays. In this work we set up a bioprospection plan to investigate the phytochemical diversity and the potential bioactivity of five Artemisia species with recognized ethnobotanical tradition (A. absinthium, A. alba, A. annua, A. verlotiorum and A. vulgaris), growing wild in the natural areas of the Verona province. We characterized the specialized metabolomes of the species (including sesquiterpenoids from the artemisinin biosynthesis pathway) through an LC–MS based untargeted approach and, in order to identify potential bioactive metabolites, we correlated their composition with the in vitro antioxidant activity. We propose as potential bioactive compounds several isomers of caffeoyl and feruloyl quinic acid esters (e.g. dicaffeoylquinic acids, feruloylquinic acids and caffeoylferuloylquinic acids), which strongly characterize the most antioxidant species A. verlotiorum and A. annua. Morevoer, in this study we report for the first time the occurrence of sesquiterpenoids from the artemisinin biosynthesis pathway in the species A. alba.https://doi.org/10.1038/s41598-024-55128-zArtemisia spp.BioprospectionAntioxidantsDicaffeoylquinic acidsSesquiterpenesArtemisinin |
| spellingShingle | Stefano Negri Fabio Pietrolucci Sebastiano Andreatta Ruth Chinyere Njoku Carolina Antunes Silva Nogueira Ramos Massimo Crimi Mauro Commisso Flavia Guzzo Linda Avesani Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds Scientific Reports Artemisia spp. Bioprospection Antioxidants Dicaffeoylquinic acids Sesquiterpenes Artemisinin |
| title | Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds |
| title_full | Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds |
| title_fullStr | Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds |
| title_full_unstemmed | Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds |
| title_short | Bioprospecting of Artemisia genus: from artemisinin to other potentially bioactive compounds |
| title_sort | bioprospecting of artemisia genus from artemisinin to other potentially bioactive compounds |
| topic | Artemisia spp. Bioprospection Antioxidants Dicaffeoylquinic acids Sesquiterpenes Artemisinin |
| url | https://doi.org/10.1038/s41598-024-55128-z |
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