The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group
Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2022-03-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/31/163/210218.full |
| _version_ | 1818364544315031552 |
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| author | Solomon Tibebu Melkie Lilibeth Arias Chiara Farroni Mateja Jankovic Makek Delia Goletti Cristina Vilaplana |
| author_facet | Solomon Tibebu Melkie Lilibeth Arias Chiara Farroni Mateja Jankovic Makek Delia Goletti Cristina Vilaplana |
| author_sort | Solomon Tibebu Melkie |
| collection | DOAJ |
| description | Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. To improve the diagnostic performance of traditional serology, a combination of different Mycobacterium tuberculosis (MTB) antigens and different antibody isotypes has been suggested, with some showing promising performance for the diagnosis of active TB. Given the incomplete protection conferred by bacille Calmette–Guérin (BCG) vaccination against adult pulmonary TB, efforts to discover novel TB vaccines are ongoing. Efficacy studies from advanced TB vaccines designed to stimulate cell-mediated immunity failed to show protection, suggesting that they may not be sufficient and warranting the need for other types of immunity. The role of antibodies as tools for TB therapy, TB diagnosis and TB vaccine design is discussed. Finally, we propose that the inclusion of antibody-based TB vaccines in current clinical trials may be advisable to improve protection. |
| first_indexed | 2024-12-13T22:06:03Z |
| format | Article |
| id | doaj.art-48e2a1f052b4477a91b65eb9f2a9771a |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-13T22:06:03Z |
| publishDate | 2022-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-48e2a1f052b4477a91b65eb9f2a9771a2022-12-21T23:29:49ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172022-03-013116310.1183/16000617.0218-20210218-2021The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study groupSolomon Tibebu Melkie0Lilibeth Arias1Chiara Farroni2Mateja Jankovic Makek3Delia Goletti4Cristina Vilaplana5 Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain Translational Research Unit, National Institute for Infectious Diseases-IRCCS L. Spallanzani, Rome, Italy Dept for Respiratory Diseases, University Clinical Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia Translational Research Unit, National Institute for Infectious Diseases-IRCCS L. Spallanzani, Rome, Italy Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain Tuberculosis (TB) is still responsible for the deaths of >1 million people yearly worldwide, and therefore its correct diagnosis is one of the key components of any TB eradication programme. However, current TB diagnostic tests have many limitations, and improved diagnostic accuracy is urgently needed. To improve the diagnostic performance of traditional serology, a combination of different Mycobacterium tuberculosis (MTB) antigens and different antibody isotypes has been suggested, with some showing promising performance for the diagnosis of active TB. Given the incomplete protection conferred by bacille Calmette–Guérin (BCG) vaccination against adult pulmonary TB, efforts to discover novel TB vaccines are ongoing. Efficacy studies from advanced TB vaccines designed to stimulate cell-mediated immunity failed to show protection, suggesting that they may not be sufficient and warranting the need for other types of immunity. The role of antibodies as tools for TB therapy, TB diagnosis and TB vaccine design is discussed. Finally, we propose that the inclusion of antibody-based TB vaccines in current clinical trials may be advisable to improve protection.http://err.ersjournals.com/content/31/163/210218.full |
| spellingShingle | Solomon Tibebu Melkie Lilibeth Arias Chiara Farroni Mateja Jankovic Makek Delia Goletti Cristina Vilaplana The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group European Respiratory Review |
| title | The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group |
| title_full | The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group |
| title_fullStr | The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group |
| title_full_unstemmed | The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group |
| title_short | The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group |
| title_sort | role of antibodies in tuberculosis diagnosis prophylaxis and therapy a review from the esgmyc study group |
| url | http://err.ersjournals.com/content/31/163/210218.full |
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