Memantine Displays Antimicrobial Activity by Enhancing Escherichia coli Pathogen-Induced Formation of Neutrophil Extracellular Traps

Memantine Displays Antimicrobial Activity by Enhancing Escherichia coli Pathogen-Induced Formation of Neutrophil Extracellular Traps

Bacterial infection remains one of the leading causes of death worldwide due to the continuous rise of multiple antibiotic-resistant bacteria. Focusing solely on bacteria as the drug targets is a major limitation inherent in the conventional antibiotic therapy. Recently, host-directed therapies have...

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Bibliographic Details
Main Authors: Liang Peng, Li Li, Xiao-Long He, Jing-Yi Yu, Zhi-Jie Zeng, Wei-Jun Yang, Bao Zhang, Tie-Song Zhang, Hong Cao, Sheng-He Huang, Li-Qun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
bacterial infection
antibiotic resistance
memantine
neutrophil extracellular traps
α7 nAChR
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00047/full

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