The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells

The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells

Ranking among the most lethal tumour entities, pancreatic duct adenocarcinoma cells invade neighbouring tissue resulting in high incidence of metastasis. They are supported by tumour stroma fibroblasts which have undergone differentiation into cancer-associated fibroblasts (CAFs). Stiffness of cell...

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Bibliographic Details
Main Authors: Ana C. Martins Cavaco, Maryam Rezaei, Michele F. Caliandro, Augusto Martins Lima, Martin Stehling, Sameer A. Dhayat, Jörg Haier, Cord Brakebusch, Johannes A. Eble
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
pancreatic cancer
cancer-associated fibroblasts (CAF)
differentiation
laminin-332
integrin α3β1
spheroid culture
invasion
Online Access:http://www.mdpi.com/2072-6694/11/1/14

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