The vagus nerve mediates the stomach-brain coherence in rats
Interactions between the brain and the stomach shape both cognitive and digestive functions. Recent human studies report spontaneous synchronization between brain activity and gastric slow waves in the resting state. However, this finding has not been replicated in any animal models. The neural path...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
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| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922007431 |
| _version_ | 1811257193689776128 |
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| author | Jiayue Cao Xiaokai Wang Jiande Chen Nanyin Zhang Zhongming Liu |
| author_facet | Jiayue Cao Xiaokai Wang Jiande Chen Nanyin Zhang Zhongming Liu |
| author_sort | Jiayue Cao |
| collection | DOAJ |
| description | Interactions between the brain and the stomach shape both cognitive and digestive functions. Recent human studies report spontaneous synchronization between brain activity and gastric slow waves in the resting state. However, this finding has not been replicated in any animal models. The neural pathways underlying this apparent stomach-brain synchrony is also unclear. Here, we performed functional magnetic resonance imaging while simultaneously recording body-surface gastric slow waves from anesthetized rats in the fasted vs. postprandial conditions and performed a bilateral cervical vagotomy to assess the role of the vagus nerve. The coherence between brain fMRI signals and gastric slow waves was found in a distributed “gastric network”, including subcortical and cortical regions in the sensory, motor, and limbic systems. The stomach-brain coherence was largely reduced by the bilateral vagotomy and was different between the fasted and fed states. These findings suggest that the vagus nerve mediates the spontaneous coherence between brain activity and gastric slow waves, which is likely a signature of real-time stomach-brain interactions. However, its functional significance remains to be established. |
| first_indexed | 2024-04-12T17:52:32Z |
| format | Article |
| id | doaj.art-48e89839e24f42c0b6ccbed1249a3116 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-12T17:52:32Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-48e89839e24f42c0b6ccbed1249a31162022-12-22T03:22:27ZengElsevierNeuroImage1095-95722022-11-01263119628The vagus nerve mediates the stomach-brain coherence in ratsJiayue Cao0Xiaokai Wang1Jiande Chen2Nanyin Zhang3Zhongming Liu4Department of Biomedical Engineering, University of Michigan, Ann Arbor, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USADivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, USADepartment of Biomedical Engineering, Huck Institutes of the life sciences, Pennsylvania State University, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, USA; Correspondence author.Interactions between the brain and the stomach shape both cognitive and digestive functions. Recent human studies report spontaneous synchronization between brain activity and gastric slow waves in the resting state. However, this finding has not been replicated in any animal models. The neural pathways underlying this apparent stomach-brain synchrony is also unclear. Here, we performed functional magnetic resonance imaging while simultaneously recording body-surface gastric slow waves from anesthetized rats in the fasted vs. postprandial conditions and performed a bilateral cervical vagotomy to assess the role of the vagus nerve. The coherence between brain fMRI signals and gastric slow waves was found in a distributed “gastric network”, including subcortical and cortical regions in the sensory, motor, and limbic systems. The stomach-brain coherence was largely reduced by the bilateral vagotomy and was different between the fasted and fed states. These findings suggest that the vagus nerve mediates the spontaneous coherence between brain activity and gastric slow waves, which is likely a signature of real-time stomach-brain interactions. However, its functional significance remains to be established.http://www.sciencedirect.com/science/article/pii/S1053811922007431 |
| spellingShingle | Jiayue Cao Xiaokai Wang Jiande Chen Nanyin Zhang Zhongming Liu The vagus nerve mediates the stomach-brain coherence in rats NeuroImage |
| title | The vagus nerve mediates the stomach-brain coherence in rats |
| title_full | The vagus nerve mediates the stomach-brain coherence in rats |
| title_fullStr | The vagus nerve mediates the stomach-brain coherence in rats |
| title_full_unstemmed | The vagus nerve mediates the stomach-brain coherence in rats |
| title_short | The vagus nerve mediates the stomach-brain coherence in rats |
| title_sort | vagus nerve mediates the stomach brain coherence in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922007431 |
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