Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats
Objective: To investigate the influence of edaravone on the expression of growth arrest and DNA damage-inducible protein 34 (GADD34). Methods: A total of 108 healthy male Sprague-Dawley rats were randomly divided into sham operation group, model group and edaravone group (36 cases for each group). T...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-09-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115300939 |
| _version_ | 1829507605337210880 |
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| author | Wei Wang Xiao-Mei Wu Bo Jiang Chun-Yu Wang Hai-Nan Zhang Xiang-Min Shen |
| author_facet | Wei Wang Xiao-Mei Wu Bo Jiang Chun-Yu Wang Hai-Nan Zhang Xiang-Min Shen |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Objective: To investigate the influence of edaravone on the expression of growth arrest and DNA damage-inducible protein 34 (GADD34).
Methods: A total of 108 healthy male Sprague-Dawley rats were randomly divided into sham operation group, model group and edaravone group (36 cases for each group). Transient focal cerebral ischemia was induced by middle cerebral artery occlusion for 2 h followed by reperfusion in Sprague-Dawley rats. Then, GADD34 expression was measured with immunohistochemistry at different time-points after reperfusion in the peri-infarct regions of all rats.
Results: The GADD34 expression was detected in the peri-infarct regions of rats 1 h after reperfusion, which reached its peak 24 h after reperfusion. And edaravone could significantly down-regulate the GADD34 expression.
Conclusions: Edaravon could down-regulate GADD34 expression, which suggests that edaravone may exert an important function in inhibiting endoplasmic reticulum stress reaction by scavenging free radicals in the upper stream. |
| first_indexed | 2024-12-16T11:10:50Z |
| format | Article |
| id | doaj.art-48e9c4caad734df1b490e44ae3ed5492 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-16T11:10:50Z |
| publishDate | 2014-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-48e9c4caad734df1b490e44ae3ed54922022-12-21T22:33:44ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-09-014971471710.12980/APJTB.4.201414B291Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in ratsWei WangXiao-Mei WuBo JiangChun-Yu WangHai-Nan ZhangXiang-Min ShenObjective: To investigate the influence of edaravone on the expression of growth arrest and DNA damage-inducible protein 34 (GADD34). Methods: A total of 108 healthy male Sprague-Dawley rats were randomly divided into sham operation group, model group and edaravone group (36 cases for each group). Transient focal cerebral ischemia was induced by middle cerebral artery occlusion for 2 h followed by reperfusion in Sprague-Dawley rats. Then, GADD34 expression was measured with immunohistochemistry at different time-points after reperfusion in the peri-infarct regions of all rats. Results: The GADD34 expression was detected in the peri-infarct regions of rats 1 h after reperfusion, which reached its peak 24 h after reperfusion. And edaravone could significantly down-regulate the GADD34 expression. Conclusions: Edaravon could down-regulate GADD34 expression, which suggests that edaravone may exert an important function in inhibiting endoplasmic reticulum stress reaction by scavenging free radicals in the upper stream.http://www.sciencedirect.com/science/article/pii/S2221169115300939EdaravoneCerebral ischemia-reperfusionGrowth arrest and DNA damage-inducible protein 34 |
| spellingShingle | Wei Wang Xiao-Mei Wu Bo Jiang Chun-Yu Wang Hai-Nan Zhang Xiang-Min Shen Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats Asian Pacific Journal of Tropical Biomedicine Edaravone Cerebral ischemia-reperfusion Growth arrest and DNA damage-inducible protein 34 |
| title | Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats |
| title_full | Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats |
| title_fullStr | Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats |
| title_full_unstemmed | Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats |
| title_short | Influence of edaravone on growth arrest and DNA damage-inducible protein 34 expression following focal cerebral ischemia-reperfusion in rats |
| title_sort | influence of edaravone on growth arrest and dna damage inducible protein 34 expression following focal cerebral ischemia reperfusion in rats |
| topic | Edaravone Cerebral ischemia-reperfusion Growth arrest and DNA damage-inducible protein 34 |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115300939 |
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