Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis
Background: This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. Methods: Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in Pu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401106W.pdf |
| _version_ | 1797319614691016704 |
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| author | Wu Delin Liu Yuna Liu Yan Cui Najuan Zhu Yan Zheng Sidao Wang Shaohua |
| author_facet | Wu Delin Liu Yuna Liu Yan Cui Najuan Zhu Yan Zheng Sidao Wang Shaohua |
| author_sort | Wu Delin |
| collection | DOAJ |
| description | Background: This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. Methods: Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in PubMed, Embase, Cochrane, Wanfang and CNKI. Eligible literatures were enrolled and their data were extracted. OR and its 95% CI were calculated for assessing the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. The included data were weighted by an inverse variance and then analyzed by a fixed or random effects model. Heterogeneity test and sensitivity analysis were performed on the enrolled reports. STATA12.1 and TSA (trial sequential analysis) were utilized for analyses. Results: Fifteen studies involving 3,791 asthma patients and 2,185 healthy controls were enrolled. No significant correlation was found between the LTC4S -444 A>C polymorphism and susceptibility to asthma according to the results of different models ((Dominant model (D): OR=1.10, 95% CI=0.98-1.23; Recessive model (R): 1.07, 0.84-1.36; Homozygous model (Homo): 1.11, 0.87-1.41; Heterozygous model (Hetero): 1.10, 0.98-1.24; Allele model (A): 1.07, 0.98-1.18). Subgroup analyses carried out in Asian and Caucasian population, as well as in population-based and hospital-based controls obtained the same conclusions. Conclusion: No significant correlation is identified between the LTC4S -444 A>C polymorphism and susceptibility to asthma. Researches with high-quality and large sample size are required for further validation in multi-center hospital. |
| first_indexed | 2024-03-08T04:10:25Z |
| format | Article |
| id | doaj.art-48eb9a88e52b43099a9dfdf2c0896f24 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-08T04:10:25Z |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-48eb9a88e52b43099a9dfdf2c0896f242024-02-08T22:37:02ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-0143110611510.5937/jomb0-445381452-82582401106WCorrelation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysisWu Delin0Liu Yuna1Liu Yan2Cui Najuan3Zhu Yan4Zheng Sidao5Wang Shaohua6Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Science & education, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Cardiology, Beijing, ChinaBeijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, ChinaBackground: This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. Methods: Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in PubMed, Embase, Cochrane, Wanfang and CNKI. Eligible literatures were enrolled and their data were extracted. OR and its 95% CI were calculated for assessing the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. The included data were weighted by an inverse variance and then analyzed by a fixed or random effects model. Heterogeneity test and sensitivity analysis were performed on the enrolled reports. STATA12.1 and TSA (trial sequential analysis) were utilized for analyses. Results: Fifteen studies involving 3,791 asthma patients and 2,185 healthy controls were enrolled. No significant correlation was found between the LTC4S -444 A>C polymorphism and susceptibility to asthma according to the results of different models ((Dominant model (D): OR=1.10, 95% CI=0.98-1.23; Recessive model (R): 1.07, 0.84-1.36; Homozygous model (Homo): 1.11, 0.87-1.41; Heterozygous model (Hetero): 1.10, 0.98-1.24; Allele model (A): 1.07, 0.98-1.18). Subgroup analyses carried out in Asian and Caucasian population, as well as in population-based and hospital-based controls obtained the same conclusions. Conclusion: No significant correlation is identified between the LTC4S -444 A>C polymorphism and susceptibility to asthma. Researches with high-quality and large sample size are required for further validation in multi-center hospital.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401106W.pdfltc4s -444 a>c polymorphismsusceptibilityasthmameta-analysis |
| spellingShingle | Wu Delin Liu Yuna Liu Yan Cui Najuan Zhu Yan Zheng Sidao Wang Shaohua Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis Journal of Medical Biochemistry ltc4s -444 a>c polymorphism susceptibility asthma meta-analysis |
| title | Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis |
| title_full | Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis |
| title_fullStr | Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis |
| title_full_unstemmed | Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis |
| title_short | Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis |
| title_sort | correlation between ltc4s 444 a c polymorphism and susceptibility to asthma a meta analysis and trial sequential analysis |
| topic | ltc4s -444 a>c polymorphism susceptibility asthma meta-analysis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401106W.pdf |
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