The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy
Immunotherapy has revolutionized cancer treatment and revitalized efforts to harness the power of the immune system to combat a variety of cancer types more effectively. However, low clinical response rates and differences in outcomes due to variations in the immune landscape among patients with can...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172931/full |
| _version_ | 1827959484807380992 |
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| author | Shonik Ganjoo Priti Gupta Halil Ibrahim Corbali Halil Ibrahim Corbali Selene Nanez Thomas S. Riad Lisa K. Duong Hampartsoum B. Barsoumian Fatemeh Masrorpour Hong Jiang James W. Welsh Maria Angelica Cortez |
| author_facet | Shonik Ganjoo Priti Gupta Halil Ibrahim Corbali Halil Ibrahim Corbali Selene Nanez Thomas S. Riad Lisa K. Duong Hampartsoum B. Barsoumian Fatemeh Masrorpour Hong Jiang James W. Welsh Maria Angelica Cortez |
| author_sort | Shonik Ganjoo |
| collection | DOAJ |
| description | Immunotherapy has revolutionized cancer treatment and revitalized efforts to harness the power of the immune system to combat a variety of cancer types more effectively. However, low clinical response rates and differences in outcomes due to variations in the immune landscape among patients with cancer continue to be major limitations to immunotherapy. Recent efforts to improve responses to immunotherapy have focused on targeting cellular metabolism, as the metabolic characteristics of cancer cells can directly influence the activity and metabolism of immune cells, particularly T cells. Although the metabolic pathways of various cancer cells and T cells have been extensively reviewed, the intersections among these pathways, and their potential use as targets for improving responses to immune-checkpoint blockade therapies, are not completely understood. This review focuses on the interplay between tumor metabolites and T-cell dysfunction as well as the relationship between several T-cell metabolic patterns and T-cell activity/function in tumor immunology. Understanding these relationships could offer new avenues for improving responses to immunotherapy on a metabolic basis. |
| first_indexed | 2024-04-09T15:52:52Z |
| format | Article |
| id | doaj.art-48ec72b18fe843dda40c79e9d8d65212 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T15:52:52Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-48ec72b18fe843dda40c79e9d8d652122023-04-26T04:46:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11729311172931The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapyShonik Ganjoo0Priti Gupta1Halil Ibrahim Corbali2Halil Ibrahim Corbali3Selene Nanez4Thomas S. Riad5Lisa K. Duong6Hampartsoum B. Barsoumian7Fatemeh Masrorpour8Hong Jiang9James W. Welsh10Maria Angelica Cortez11Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TürkiyeDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesImmunotherapy has revolutionized cancer treatment and revitalized efforts to harness the power of the immune system to combat a variety of cancer types more effectively. However, low clinical response rates and differences in outcomes due to variations in the immune landscape among patients with cancer continue to be major limitations to immunotherapy. Recent efforts to improve responses to immunotherapy have focused on targeting cellular metabolism, as the metabolic characteristics of cancer cells can directly influence the activity and metabolism of immune cells, particularly T cells. Although the metabolic pathways of various cancer cells and T cells have been extensively reviewed, the intersections among these pathways, and their potential use as targets for improving responses to immune-checkpoint blockade therapies, are not completely understood. This review focuses on the interplay between tumor metabolites and T-cell dysfunction as well as the relationship between several T-cell metabolic patterns and T-cell activity/function in tumor immunology. Understanding these relationships could offer new avenues for improving responses to immunotherapy on a metabolic basis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172931/fullmetabolismT cellcancerimmunotherapytumor immune microenvironment |
| spellingShingle | Shonik Ganjoo Priti Gupta Halil Ibrahim Corbali Halil Ibrahim Corbali Selene Nanez Thomas S. Riad Lisa K. Duong Hampartsoum B. Barsoumian Fatemeh Masrorpour Hong Jiang James W. Welsh Maria Angelica Cortez The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy Frontiers in Immunology metabolism T cell cancer immunotherapy tumor immune microenvironment |
| title | The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy |
| title_full | The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy |
| title_fullStr | The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy |
| title_full_unstemmed | The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy |
| title_short | The role of tumor metabolism in modulating T-Cell activity and in optimizing immunotherapy |
| title_sort | role of tumor metabolism in modulating t cell activity and in optimizing immunotherapy |
| topic | metabolism T cell cancer immunotherapy tumor immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172931/full |
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