Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer

Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer

Abstract Background Altered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks of colorectal cancer (CRC). Here we performed concurrent 16S rRNA gene sequencing and methyl-CpG binding domain-based capture sequencing in 33 tissue...

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Bibliographic Details
Main Authors: Xiaoxuan Xia, William Ka Kei Wu, Sunny Hei Wong, Dabin Liu, Thomas Ngai Yeung Kwong, Geicho Nakatsu, Pearlly S. Yan, Yu-Ming Chuang, Michael Wing-Yan Chan, Olabisi Oluwabukola Coker, Zigui Chen, Yun Kit Yeoh, Liuyang Zhao, Xiansong Wang, Wing Yin Cheng, Matthew Tak Vai Chan, Paul Kay Sheung Chan, Joseph Jao Yiu Sung, Maggie Haitian Wang, Jun Yu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Microbiome
Subjects:
Colorectal cancer
Microbiota
DNA methylation
MBDCap-Seq
DNMT
Online Access:http://link.springer.com/article/10.1186/s40168-020-00847-4

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