Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines
Abstract Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An a...
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2017-03-01
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| Series: | SynOpen |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1590963 |
| _version_ | 1818290294394716160 |
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| author | Yi-Qiu Yang Long-Zhi Ke Gui-Fei Wang Shu-Yong Song Ming-Ning Qiu Jian-Jun Liu Yun-Sheng Huang |
| author_facet | Yi-Qiu Yang Long-Zhi Ke Gui-Fei Wang Shu-Yong Song Ming-Ning Qiu Jian-Jun Liu Yun-Sheng Huang |
| author_sort | Yi-Qiu Yang |
| collection | DOAJ |
| description | Abstract
Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An additional coordinating bond can be formed between the metal ion and a neutral molecule of nitric oxide (NO). The resultant complexes are potentially useful agents for targeted delivery of NO to in vivo biological sites such as tumors, where the NO is released upon irradiation with long-wavelength light. Initial work involving the synthesis and characterization of these analogues is reported here. |
| first_indexed | 2024-12-13T02:25:53Z |
| format | Article |
| id | doaj.art-48eede8da61b46fabb0f473848607196 |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-12-13T02:25:53Z |
| publishDate | 2017-03-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-48eede8da61b46fabb0f4738486071962022-12-22T00:02:38ZengGeorg Thieme Verlag KGSynOpen2509-93962017-03-0101010147015510.1055/s-0036-1590963Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diaminesYi-Qiu Yang0Long-Zhi Ke1Gui-Fei Wang2Shu-Yong Song3Ming-Ning Qiu4Jian-Jun Liu5Yun-Sheng Huang6School of Pharmacy, Guangdong Medical UniversityLaboratory of Urology, Guangdong Medical UniversitySchool of Pharmacy, Guangdong Medical UniversitySchool of Pharmacy, Guangdong Medical UniversityLaboratory of Urology, Guangdong Medical UniversityLaboratory of Urology, Guangdong Medical UniversitySchool of Pharmacy, Guangdong Medical UniversityAbstract Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An additional coordinating bond can be formed between the metal ion and a neutral molecule of nitric oxide (NO). The resultant complexes are potentially useful agents for targeted delivery of NO to in vivo biological sites such as tumors, where the NO is released upon irradiation with long-wavelength light. Initial work involving the synthesis and characterization of these analogues is reported here.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1590963ligandsnitric oxidedonorpyridine-2-ylmethylquinolin-2-ylmethyl |
| spellingShingle | Yi-Qiu Yang Long-Zhi Ke Gui-Fei Wang Shu-Yong Song Ming-Ning Qiu Jian-Jun Liu Yun-Sheng Huang Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines SynOpen ligands nitric oxide donor pyridine-2-ylmethyl quinolin-2-ylmethyl |
| title | Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines |
| title_full | Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines |
| title_fullStr | Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines |
| title_full_unstemmed | Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines |
| title_short | Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl Substituted Ethane-1,2-diamines |
| title_sort | synthesis of n pyridin 2 ylmethyl and n quinolin 2 ylmethyl substituted ethane 1 2 diamines |
| topic | ligands nitric oxide donor pyridine-2-ylmethyl quinolin-2-ylmethyl |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1590963 |
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