Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer.
<h4>Background</h4>Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.<h4>Objective</h4>This study aimed to investigate the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0272308 |
| _version_ | 1811285991379435520 |
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| author | Fahmy T Ali Reham M Soliman Nahla S Hassan Ahmed M Ibrahim Mayada M El-Gizawy Abd Allah Y Mandoh Ehab A Ibrahim |
| author_facet | Fahmy T Ali Reham M Soliman Nahla S Hassan Ahmed M Ibrahim Mayada M El-Gizawy Abd Allah Y Mandoh Ehab A Ibrahim |
| author_sort | Fahmy T Ali |
| collection | DOAJ |
| description | <h4>Background</h4>Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.<h4>Objective</h4>This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.<h4>Subjects & methods</h4>The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.<h4>Results</h4>The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively.<h4>Conclusion</h4>The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer. |
| first_indexed | 2024-04-13T02:53:06Z |
| format | Article |
| id | doaj.art-48ef6f22c700425e939cbac5d0c97c86 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T02:53:06Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-48ef6f22c700425e939cbac5d0c97c862022-12-22T03:05:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027230810.1371/journal.pone.0272308Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer.Fahmy T AliReham M SolimanNahla S HassanAhmed M IbrahimMayada M El-GizawyAbd Allah Y MandohEhab A Ibrahim<h4>Background</h4>Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.<h4>Objective</h4>This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.<h4>Subjects & methods</h4>The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.<h4>Results</h4>The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. The sensitivities of miRNA-204, CA125, and CA19.9 were 98.04%, 100.00%, and 96.19% and the specificities were 58.33%, 62.50%, and 57.78%, respectively.<h4>Conclusion</h4>The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic tool for ovarian cancer.https://doi.org/10.1371/journal.pone.0272308 |
| spellingShingle | Fahmy T Ali Reham M Soliman Nahla S Hassan Ahmed M Ibrahim Mayada M El-Gizawy Abd Allah Y Mandoh Ehab A Ibrahim Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. PLoS ONE |
| title | Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. |
| title_full | Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. |
| title_fullStr | Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. |
| title_full_unstemmed | Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. |
| title_short | Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer. |
| title_sort | sensitivity and specificity of microrna 204 ca125 and ca19 9 as biomarkers for diagnosis of ovarian cancer |
| url | https://doi.org/10.1371/journal.pone.0272308 |
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