Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract
Complex multiple emulsions have an excellent ability to fill large volumes of functional cosmetic agents. This study was aimed to encapsulate large volume of green tea in classical multiple emulsion and to compare its stability with a multiple emulsion without green tea extract. Multiple emulsions w...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2013-06-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200016&lng=en&tlng=en |
| _version_ | 1818755065035358208 |
|---|---|
| author | Tariq Mahmood Naveed Akhtar Barkat Ali Khan Akhtar Rasul Haji M. Shoaib Khan |
| author_facet | Tariq Mahmood Naveed Akhtar Barkat Ali Khan Akhtar Rasul Haji M. Shoaib Khan |
| author_sort | Tariq Mahmood |
| collection | DOAJ |
| description | Complex multiple emulsions have an excellent ability to fill large volumes of functional cosmetic agents. This study was aimed to encapsulate large volume of green tea in classical multiple emulsion and to compare its stability with a multiple emulsion without green tea extract. Multiple emulsions were developed using Cetyl dimethicone copolyol as lipophilic emulsifier and classic polysorbate-80 as hydrophilic emulsifier. Multiple emulsions were evaluated for various physicochemical aspects like conductivity, pH, microscopic analysis, rheology and these characteristics were followed for a period of 30 days in different storage conditions. In vitro and in vivo skin protection tests were also performed for both kinds of multiple emulsions i.e. with active (MeA) and without active (MeB). Both formulations showed comparable characteristics regarding various physicochemical characteristics in different storage conditions. Rheological analysis showed that formulations showed pseudo plastic behavior upon continuous shear stress. Results of in vitro and in vivo skin protection data have revealed that the active formulation has comparable skin protection effects to that of control formulation. It was presumed that stable multiple emulsions could be a promising choice for topical application of green tea but multiple emulsions presented in this study need improvement in the formula, concluded on the basis of pH, conductivity and apparent viscosity data. |
| first_indexed | 2024-12-18T05:33:13Z |
| format | Article |
| id | doaj.art-48efe532509f48f0ad010c6f227cbc6a |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-18T05:33:13Z |
| publishDate | 2013-06-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-48efe532509f48f0ad010c6f227cbc6a2022-12-21T21:19:24ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902013-06-0149234134910.1590/S1984-82502013000200016S1984-82502013000200016Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extractTariq Mahmood0Naveed Akhtar1Barkat Ali Khan2Akhtar Rasul3Haji M. Shoaib Khan4Islamia University BahawalpurIslamia University BahawalpurIslamia University BahawalpurIslamia University BahawalpurIslamia University BahawalpurComplex multiple emulsions have an excellent ability to fill large volumes of functional cosmetic agents. This study was aimed to encapsulate large volume of green tea in classical multiple emulsion and to compare its stability with a multiple emulsion without green tea extract. Multiple emulsions were developed using Cetyl dimethicone copolyol as lipophilic emulsifier and classic polysorbate-80 as hydrophilic emulsifier. Multiple emulsions were evaluated for various physicochemical aspects like conductivity, pH, microscopic analysis, rheology and these characteristics were followed for a period of 30 days in different storage conditions. In vitro and in vivo skin protection tests were also performed for both kinds of multiple emulsions i.e. with active (MeA) and without active (MeB). Both formulations showed comparable characteristics regarding various physicochemical characteristics in different storage conditions. Rheological analysis showed that formulations showed pseudo plastic behavior upon continuous shear stress. Results of in vitro and in vivo skin protection data have revealed that the active formulation has comparable skin protection effects to that of control formulation. It was presumed that stable multiple emulsions could be a promising choice for topical application of green tea but multiple emulsions presented in this study need improvement in the formula, concluded on the basis of pH, conductivity and apparent viscosity data.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200016&lng=en&tlng=enCosméticosChá verdeMúltipla emulsãoReologiaPeleEstabilidade |
| spellingShingle | Tariq Mahmood Naveed Akhtar Barkat Ali Khan Akhtar Rasul Haji M. Shoaib Khan Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract Brazilian Journal of Pharmaceutical Sciences Cosméticos Chá verde Múltipla emulsão Reologia Pele Estabilidade |
| title | Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract |
| title_full | Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract |
| title_fullStr | Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract |
| title_full_unstemmed | Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract |
| title_short | Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract |
| title_sort | fabrication physicochemical characterization and preliminary efficacy evaluation of a w o w multiple emulsion loaded with 5 green tea extract |
| topic | Cosméticos Chá verde Múltipla emulsão Reologia Pele Estabilidade |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200016&lng=en&tlng=en |
| work_keys_str_mv | AT tariqmahmood fabricationphysicochemicalcharacterizationandpreliminaryefficacyevaluationofawowmultipleemulsionloadedwith5greenteaextract AT naveedakhtar fabricationphysicochemicalcharacterizationandpreliminaryefficacyevaluationofawowmultipleemulsionloadedwith5greenteaextract AT barkatalikhan fabricationphysicochemicalcharacterizationandpreliminaryefficacyevaluationofawowmultipleemulsionloadedwith5greenteaextract AT akhtarrasul fabricationphysicochemicalcharacterizationandpreliminaryefficacyevaluationofawowmultipleemulsionloadedwith5greenteaextract AT hajimshoaibkhan fabricationphysicochemicalcharacterizationandpreliminaryefficacyevaluationofawowmultipleemulsionloadedwith5greenteaextract |