LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB

LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB

Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide but has no effective treatment. Amyloid beta (Aβ) protein, a primary risk factor for AD, accumulates and aggregates in the brain of patients with AD. Paired immunoglobulin-like receptor B (PirB) has b...

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Bibliographic Details
Main Authors: Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara, Kohtaro Takei
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Medicine
Subjects:
Amyloid beta protein
Alzheimer’s disease
Paired immunoglobulin-like receptor B
Lateral olfactory tract usher substance
Cofilin
Post-synaptic density-95
Online Access:https://doi.org/10.1186/s10020-022-00581-7

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