Tumor-specific T cells signal tumor destruction via the lymphotoxin β receptor

Tumor-specific T cells signal tumor destruction via the lymphotoxin β receptor

<p>Abstract</p> <p>Background</p> <p>Previously, we reported that adoptively transferred perforin k/o (PKO), and IFN-γ k/o (GKO), or perforin/IFN-γ double k/o (PKO/GKO) effector T cells mediated regression of B16BL6-D5 (D5) pulmonary metastases and showed that TNF recep...

Full description

Bibliographic Details
Main Authors:	Fox Bernard A, Hatz Rudolf A, Poehlein Christian H, van den Engel Natasja K, Winter Hauke, Hu Hong-Ming
Format:	Article
Language:	English
Published:	BMC 2007-03-01
Series:	Journal of Translational Medicine
Online Access:	http://www.translational-medicine.com/content/5/1/14

Similar Items

The tumor necrosis factor superfamily members TNFSF14 (LIGHT), lymphotoxin β and lymphotoxin β receptor interact to regulate intestinal inflammation
by: Giles, DA, et al.
Published: (2018)

Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer
by: van den Engel Natasja K, et al.
Published: (2011-08-01)

Anti-Gr-1 Antibody Provides Short-Term Depletion of MDSC in Lymphodepleted Mice with Active-Specific Melanoma Therapy
by: Peter Rose, et al.
Published: (2022-04-01)

Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils
by: Riffelmacher, T, et al.
Published: (2021)

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling
by: Magdalena Banach-Orłowska, et al.
Published: (2019-12-01)

Characterization of gastric adenocarcinoma cell lines established from CEA424/<it>SV40 T antigen</it>-transgenic mice with or without a human <it>CEA </it>transgene
by: Hatz Rudolf A, et al.
Published: (2006-03-01)

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
by: Clark, T, et al.
Published: (2009)

Arming ColoAd1 with tumor necrosis factor alpha and lymphotoxin alpha
by: Koelen, J
Published: (2015)

Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells.
by: Yu Mikami, et al.
Published: (2014-01-01)

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration
by: Zhu Guo, et al.
Published: (2021-01-01)

[Cloning and characteristics of the human genome locus containing genes of a second type of receptor (75 kDa) for tumor necrosis factor and lymphotoxin]
by: Turetskaia, R, et al.
Published: (1991)

Cloning and characteristics of the human genome locus containing genes of a second type of receptor (75 kDa) for tumor necrosis factor and lymphotoxin
by: Turetskaia, R, et al.
Published: (1991)

RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis.
by: Ayumu Takeshita, et al.
Published: (2021-01-01)

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor
by: Małgorzata Maksymowicz, et al.
Published: (2020-11-01)

Genomic organization and phylogenetic utility of deer mouse (<it>Peromyscus maniculatus</it>) lymphotoxin-alpha and lymphotoxin-beta
by: Prescott Joseph, et al.
Published: (2008-10-01)

Lymphotoxin expression in human and murine renal allografts.
by: Harald Seeger, et al.
Published: (2018-01-01)

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
by: C. Colin Brinkman, et al.
Published: (2016-06-01)

Tumor necrosis factor-α and lymphotoxin-α mediate myocardial ischemic injury via TNF receptor 1, but are cardioprotective when activating TNF receptor 2.
by: Yanqing Zhang, et al.
Published: (2013-01-01)

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.
by: Nedospasov, SA, et al.
Published: (1991)

The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.
by: Newton, J, et al.
Published: (2003)

Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response
by: Schendel Dolores J, et al.
Published: (2007-09-01)

Growth of Murine Splenic Tissue Is Suppressed by Lymphotoxin β-Receptor Signaling (LTβR) Originating from Splenic and Non-Splenic Tissues.
by: Novica M Milićević, et al.
Published: (2016-01-01)

Lymphotoxin-sensitive microenvironments in homeostasis and inflammation
by: Bryant eBoulianne, et al.
Published: (2012-07-01)

Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha
by: Lazaros Vasilikos, et al.
Published: (2021-02-01)

Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.
by: Knight, J, et al.
Published: (2004)

Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle
by: Manuel Schmidt, et al.
Published: (2021-10-01)

Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis.
by: Ragoussis, J, et al.
Published: (1988)

Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood
by: Yajun Shou, et al.
Published: (2021-07-01)

Soluble lymphotoxin is an important effector molecule in GVHD and GVL.
by: Markey, K, et al.
Published: (2010)

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
by: Heikenwalder, M, et al.
Published: (2008)

Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.
by: Boraska, V, et al.
Published: (2009)

Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-Β gene
by: Wicks, K, et al.
Published: (2011)

Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-β gene.
by: Wicks, K, et al.
Published: (2011)

Transcriptome Analysis Identifies Accumulation of Natural Killer Cells with Enhanced Lymphotoxin-β Expression during Glioblastoma Progression
by: Gianni Monaco, et al.
Published: (2022-10-01)

Methylene tetrahydrofolate reductase, transforming growth factor-β1 and lymphotoxin-α genes polymorphisms and susceptibility to rheumatoid arthritis
by: Olfat G. Shaker, et al.

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation.
by: Frohman, E, et al.
Published: (1989)

Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.
by: Yannick Simonin, et al.
Published: (2013-03-01)

Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
by: Shi-Wei Liu, et al.
Published: (2022-06-01)

Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis.
by: Jadwiga Bienkowska, et al.
Published: (2014-01-01)

Functional characterization of rs2229094 (T>C) polymorphism in the tumor necrosis factor locus and lymphotoxin alpha expression in human retina: the Retina 4 project
by: Pastor-Idoate S, et al.
Published: (2017-05-01)