High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland
Cytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15–49 basing on existing se...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-12-01
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| Series: | Polish Journal of Microbiology |
| Subjects: | |
| Online Access: | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227668.pdf |
| _version_ | 1811220727218569216 |
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| author | Joanna Siennicka Milena Dunal-Szczepaniak Agnieszka Trzcińska Paulina Godzik Magdalena Rosińska |
| author_facet | Joanna Siennicka Milena Dunal-Szczepaniak Agnieszka Trzcińska Paulina Godzik Magdalena Rosińska |
| author_sort | Joanna Siennicka |
| collection | DOAJ |
| description | Cytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15–49 basing on existing serum bank. Age dependent CMV incidence, the rates of congenital infection and sequelae were modelled from sero-prevalence, literature and demographic data. The overall anti-CMV IgG prevalence was 81.9% increasing from 74.3% in < 30 years old to 94.3% in subjects 45+ years old. The lowest incidence was estimated at the age of 15 and the highest at the age 34 (3.8 and 8.95 respec­tively/100 women/year). The estimated rate of cCMV varies from 22.4 to 37.2 per 1000 live birth depending on the assumptions made. The proportion of cases due to secondary infection ranged from 34.8% to 49.9% accordingly. |
| first_indexed | 2024-04-12T07:47:36Z |
| format | Article |
| id | doaj.art-48f106d59e5a4902bcf5112649b7ff83 |
| institution | Directory Open Access Journal |
| issn | 1733-1331 2544-4646 |
| language | English |
| last_indexed | 2024-04-12T07:47:36Z |
| publishDate | 2016-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Polish Journal of Microbiology |
| spelling | doaj.art-48f106d59e5a4902bcf5112649b7ff832022-12-22T03:41:40ZengSciendoPolish Journal of Microbiology1733-13312544-46462016-12-0165410.5604/17331331.1227668High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in PolandJoanna Siennicka0Milena Dunal-Szczepaniak1Agnieszka Trzcińska2Paulina Godzik3Magdalena Rosińska4Department of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandDepartment of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandDepartment of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandDepartment of Virology, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandDepartment of Epidemiology, National Institute of Public Health – National Institute of Hygiene, Warsaw, PolandCytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15–49 basing on existing serum bank. Age dependent CMV incidence, the rates of congenital infection and sequelae were modelled from sero-prevalence, literature and demographic data. The overall anti-CMV IgG prevalence was 81.9% increasing from 74.3% in < 30 years old to 94.3% in subjects 45+ years old. The lowest incidence was estimated at the age of 15 and the highest at the age 34 (3.8 and 8.95 respec­tively/100 women/year). The estimated rate of cCMV varies from 22.4 to 37.2 per 1000 live birth depending on the assumptions made. The proportion of cases due to secondary infection ranged from 34.8% to 49.9% accordingly.https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227668.pdfCMV IgG prevalenceCMV in Polandcongenital CMV infectioncongenital CMV sequelaewomen of childbearing age |
| spellingShingle | Joanna Siennicka Milena Dunal-Szczepaniak Agnieszka Trzcińska Paulina Godzik Magdalena Rosińska High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland Polish Journal of Microbiology CMV IgG prevalence CMV in Poland congenital CMV infection congenital CMV sequelae women of childbearing age |
| title | High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland |
| title_full | High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland |
| title_fullStr | High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland |
| title_full_unstemmed | High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland |
| title_short | High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland |
| title_sort | high seroprevalence of cmv among women of childbearing age implicates high burden of congenital cytomegalovirus infection in poland |
| topic | CMV IgG prevalence CMV in Poland congenital CMV infection congenital CMV sequelae women of childbearing age |
| url | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/65/4/pdf/10.5604_17331331.1227668.pdf |
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