Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells

Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells

Chronic liver inflammation can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Kupffer cells (KC) secrete proinflammatory and fibrogenic cytokines in response to lipopolysaccharide (LPS), and so play an important role in liver inflammation, where they induce hepatocellular damage. LPS als...

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Bibliographic Details
Main Authors: Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Sol Han, Mi Kyung Kim, Byoung Kuk Jang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
evogliptin
Kupffer cells
hepatocytes
hepatic stellate cells
LPS
TGF-β
Online Access:https://www.mdpi.com/1422-0067/23/19/11636

Internet

https://www.mdpi.com/1422-0067/23/19/11636

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