Oocyte cryopreservation - current scenario and future perspectives: A narrative review
Oocyte cryopreservation is a boon for women undergoing assisted reproductive technology. With the evolution in the technique of cryopreservation over the last three decades, there has been an exponential rise in the number of oocyte cryopreservation cycles for diverse indications. Apart from cancer...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=340;epage=349;aulast=Pai |
| _version_ | 1798033765410275328 |
|---|---|
| author | Hrishikesh D Pai Rashmi Baid Nandita P Palshetkar Arnav Pai Rishma D Pai Rohan Palshetkar |
| author_facet | Hrishikesh D Pai Rashmi Baid Nandita P Palshetkar Arnav Pai Rishma D Pai Rohan Palshetkar |
| author_sort | Hrishikesh D Pai |
| collection | DOAJ |
| description | Oocyte cryopreservation is a boon for women undergoing assisted reproductive technology. With the evolution in the technique of cryopreservation over the last three decades, there has been an exponential rise in the number of oocyte cryopreservation cycles for diverse indications. Apart from cancer patients, it has also been promoted as a mode of fertility insurance to overcome the age-related decline in fertility as well as post-surgical decline following endometriosis surgery. The objective of the review is to evaluate its clinical applications, ideal age at freezing, optimal oocyte number, freezing method of choice, efficacy, safety and recent advances. In the last decade, vitrification has surpassed slow freezing for oocyte cryopreservation. Although closed system of vitrification provides the aseptic environment, open vitrification is commonly followed in practice. Early to mid-thirties is a reasonable age group for planned oocyte cryopreservation, although it might be recommended at a younger age, in patients with diminished ovarian reserve. The patients should be motivated to preserve around 14–20 mature oocytes for successful live birth. Various studies have shown comparable fertilisation and pregnancy rates between Intracytoplasmic sperm injection with fresh and frozen-thawed oocytes. The available evidence has shown no increase in the incidence of congenital abnormalities in babies born through vitrified oocytes. In the future, image analysis using artificial intelligence, and spindle visualisation using poloscope may further enhance the outcome of oocyte cryopreservation. |
| first_indexed | 2024-04-11T20:35:04Z |
| format | Article |
| id | doaj.art-48f252dc139241218d7d9de89aeae0bd |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-04-11T20:35:04Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-48f252dc139241218d7d9de89aeae0bd2022-12-22T04:04:24ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662021-01-0114434034910.4103/jhrs.jhrs_173_21Oocyte cryopreservation - current scenario and future perspectives: A narrative reviewHrishikesh D PaiRashmi BaidNandita P PalshetkarArnav PaiRishma D PaiRohan PalshetkarOocyte cryopreservation is a boon for women undergoing assisted reproductive technology. With the evolution in the technique of cryopreservation over the last three decades, there has been an exponential rise in the number of oocyte cryopreservation cycles for diverse indications. Apart from cancer patients, it has also been promoted as a mode of fertility insurance to overcome the age-related decline in fertility as well as post-surgical decline following endometriosis surgery. The objective of the review is to evaluate its clinical applications, ideal age at freezing, optimal oocyte number, freezing method of choice, efficacy, safety and recent advances. In the last decade, vitrification has surpassed slow freezing for oocyte cryopreservation. Although closed system of vitrification provides the aseptic environment, open vitrification is commonly followed in practice. Early to mid-thirties is a reasonable age group for planned oocyte cryopreservation, although it might be recommended at a younger age, in patients with diminished ovarian reserve. The patients should be motivated to preserve around 14–20 mature oocytes for successful live birth. Various studies have shown comparable fertilisation and pregnancy rates between Intracytoplasmic sperm injection with fresh and frozen-thawed oocytes. The available evidence has shown no increase in the incidence of congenital abnormalities in babies born through vitrified oocytes. In the future, image analysis using artificial intelligence, and spindle visualisation using poloscope may further enhance the outcome of oocyte cryopreservation.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=340;epage=349;aulast=Paifertility preservationoocyte cryopreservationsocial egg freezing |
| spellingShingle | Hrishikesh D Pai Rashmi Baid Nandita P Palshetkar Arnav Pai Rishma D Pai Rohan Palshetkar Oocyte cryopreservation - current scenario and future perspectives: A narrative review Journal of Human Reproductive Sciences fertility preservation oocyte cryopreservation social egg freezing |
| title | Oocyte cryopreservation - current scenario and future perspectives: A narrative review |
| title_full | Oocyte cryopreservation - current scenario and future perspectives: A narrative review |
| title_fullStr | Oocyte cryopreservation - current scenario and future perspectives: A narrative review |
| title_full_unstemmed | Oocyte cryopreservation - current scenario and future perspectives: A narrative review |
| title_short | Oocyte cryopreservation - current scenario and future perspectives: A narrative review |
| title_sort | oocyte cryopreservation current scenario and future perspectives a narrative review |
| topic | fertility preservation oocyte cryopreservation social egg freezing |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=340;epage=349;aulast=Pai |
| work_keys_str_mv | AT hrishikeshdpai oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview AT rashmibaid oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview AT nanditappalshetkar oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview AT arnavpai oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview AT rishmadpai oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview AT rohanpalshetkar oocytecryopreservationcurrentscenarioandfutureperspectivesanarrativereview |