New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source

New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source

Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal and Neu5Gc. Besides knockout (KO) of genes responsib...

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Bibliographic Details
Main Authors: Hanna Tritschler, Konrad Fischer, Jochen Seissler, Jörg Fiedler, Rebecca Halbgebauer, Markus Huber-Lang, Angelika Schnieke, Rolf E. Brenner
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
porcine chondrocytes
xenotransplantation
complement
α-1,3-Gal-epitope
Neu5Gc-epitope
CD46
Online Access:https://www.mdpi.com/2073-4409/10/8/2152

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