Periostin as a Biomarker of Bronchial Asthma
Immune inflammation regulated by CD4+ cells (T cells type 2) is integral to the pathogenesis of most cases of bronchial asthma (BA). However, not all mechanisms of chronic inflammation in BA are studied well enough. More recently the role of periostin (extracellular matrix protein) in development of...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2020-01-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2231 |
| _version_ | 1826561792703201280 |
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| author | Natalia V. Shakhova |
| author_facet | Natalia V. Shakhova |
| author_sort | Natalia V. Shakhova |
| collection | DOAJ |
| description | Immune inflammation regulated by CD4+ cells (T cells type 2) is integral to the pathogenesis of most cases of bronchial asthma (BA). However, not all mechanisms of chronic inflammation in BA are studied well enough. More recently the role of periostin (extracellular matrix protein) in development of eosinophilic inflammation and airway remodeling at BA has been revealed. The effect of periostin on BA course and development can be confirmed by its high expression in bronchial epithelium of patients with BA. This review shows current data on periostin structure and synthesis, correlation between periostin and BA course and development and pulmonary function test. Special attention is given to the periostin role in BA in children. |
| first_indexed | 2024-03-12T04:47:50Z |
| format | Article |
| id | doaj.art-48f6ed7be98f48f4af4317d9ce5ed621 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:37:49Z |
| publishDate | 2020-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-48f6ed7be98f48f4af4317d9ce5ed6212025-03-02T11:34:22Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352020-01-0118533934510.15690/vsp.v18i5.20561835Periostin as a Biomarker of Bronchial AsthmaNatalia V. Shakhova0Altai State Medical University; Siberian State Medical UniversityImmune inflammation regulated by CD4+ cells (T cells type 2) is integral to the pathogenesis of most cases of bronchial asthma (BA). However, not all mechanisms of chronic inflammation in BA are studied well enough. More recently the role of periostin (extracellular matrix protein) in development of eosinophilic inflammation and airway remodeling at BA has been revealed. The effect of periostin on BA course and development can be confirmed by its high expression in bronchial epithelium of patients with BA. This review shows current data on periostin structure and synthesis, correlation between periostin and BA course and development and pulmonary function test. Special attention is given to the periostin role in BA in children.https://vsp.spr-journal.ru/jour/article/view/2231childrenbronchial asthmaperiostineosinophilic inflammationairway remodelingpulmonary function test |
| spellingShingle | Natalia V. Shakhova Periostin as a Biomarker of Bronchial Asthma Вопросы современной педиатрии children bronchial asthma periostin eosinophilic inflammation airway remodeling pulmonary function test |
| title | Periostin as a Biomarker of Bronchial Asthma |
| title_full | Periostin as a Biomarker of Bronchial Asthma |
| title_fullStr | Periostin as a Biomarker of Bronchial Asthma |
| title_full_unstemmed | Periostin as a Biomarker of Bronchial Asthma |
| title_short | Periostin as a Biomarker of Bronchial Asthma |
| title_sort | periostin as a biomarker of bronchial asthma |
| topic | children bronchial asthma periostin eosinophilic inflammation airway remodeling pulmonary function test |
| url | https://vsp.spr-journal.ru/jour/article/view/2231 |
| work_keys_str_mv | AT nataliavshakhova periostinasabiomarkerofbronchialasthma |