The Impact of RSV Hospitalization on Children’s Quality of Life
Background: Respiratory syncytial virus (RSV) is one of the most frequent etiological factors of lower respiratory tract infections in children, potentially affecting patients’ quality of life (QoL). We aimed to asses QoL in children under 2 years of age hospitalized due to laboratory-confirmed RSV...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/11/3/111 |
| _version_ | 1797580599442014208 |
|---|---|
| author | August Wrotek Oliwia Wrotek Teresa Jackowska |
| author_facet | August Wrotek Oliwia Wrotek Teresa Jackowska |
| author_sort | August Wrotek |
| collection | DOAJ |
| description | Background: Respiratory syncytial virus (RSV) is one of the most frequent etiological factors of lower respiratory tract infections in children, potentially affecting patients’ quality of life (QoL). We aimed to asses QoL in children under 2 years of age hospitalized due to laboratory-confirmed RSV infection. Methods: A QoL was assessed by parents/tutors with the use of the 100-point visual analog scale and compared against a disease-free period. We evaluated the median utility, QoL loss (reported in days), and quality-adjusted life years (QALY) loss in relation to RSV hospitalization. Results: We included 132 patients aged from 17 days to 24 months (median 3.8 months). The mean utility during the hospitalization varied between 0.418 and 0.952, with a median of 0.679 (95%CI: 0.6–0.757) and median loss of 0.321 [0.243–0.4], which further translated into a loss of 2.2 days (95%CI: 1.6–3.1). The QALY loss varied between 0.526 × 10<sup>−3</sup> and 24.658 × 10<sup>−3</sup>, with a median of 6.03 × 10<sup>−3</sup> (95%CI: 4.38–8.48 × 10<sup>−3</sup>). Based upon the final diagnoses, the highest QALY loss was 6.99 × 10<sup>−3</sup> (95%CI: 5.29–13.7 × 10<sup>−3</sup>) for pneumonia, followed by bronchiolitis—5.96 × 10<sup>−3</sup> (4.25–8.41 × 10<sup>−3</sup>) and bronchitis—4.92 × 10<sup>−3</sup> (2.93–6.03 × 10<sup>−3</sup>); significant differences were observed only between bronchitis and pneumonia (<i>p</i> = 0.0171); the QALY loss was not age-dependent. Although an increasing tendency in the utility score was observed, a strong cumulative effect related to the length of stay was noted until day 13. Conclusions: RSV contributes significantly to the utility deterioration and QALY loss in the case of RSV hospitalization, and the patient-reported data should be used in pharmacoeconomic assessments of the impact of RSV. |
| first_indexed | 2024-03-10T22:52:01Z |
| format | Article |
| id | doaj.art-48f7326e3e044d3992393371f0516bac |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T22:52:01Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-48f7326e3e044d3992393371f0516bac2023-11-19T10:15:25ZengMDPI AGDiseases2079-97212023-08-0111311110.3390/diseases11030111The Impact of RSV Hospitalization on Children’s Quality of LifeAugust Wrotek0Oliwia Wrotek1Teresa Jackowska2Department of Pediatrics, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813 Warsaw, PolandStudent Research Group, Bielanski Hospital, 80 Cegłowska Str., 01-809 Warsaw, PolandDepartment of Pediatrics, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813 Warsaw, PolandBackground: Respiratory syncytial virus (RSV) is one of the most frequent etiological factors of lower respiratory tract infections in children, potentially affecting patients’ quality of life (QoL). We aimed to asses QoL in children under 2 years of age hospitalized due to laboratory-confirmed RSV infection. Methods: A QoL was assessed by parents/tutors with the use of the 100-point visual analog scale and compared against a disease-free period. We evaluated the median utility, QoL loss (reported in days), and quality-adjusted life years (QALY) loss in relation to RSV hospitalization. Results: We included 132 patients aged from 17 days to 24 months (median 3.8 months). The mean utility during the hospitalization varied between 0.418 and 0.952, with a median of 0.679 (95%CI: 0.6–0.757) and median loss of 0.321 [0.243–0.4], which further translated into a loss of 2.2 days (95%CI: 1.6–3.1). The QALY loss varied between 0.526 × 10<sup>−3</sup> and 24.658 × 10<sup>−3</sup>, with a median of 6.03 × 10<sup>−3</sup> (95%CI: 4.38–8.48 × 10<sup>−3</sup>). Based upon the final diagnoses, the highest QALY loss was 6.99 × 10<sup>−3</sup> (95%CI: 5.29–13.7 × 10<sup>−3</sup>) for pneumonia, followed by bronchiolitis—5.96 × 10<sup>−3</sup> (4.25–8.41 × 10<sup>−3</sup>) and bronchitis—4.92 × 10<sup>−3</sup> (2.93–6.03 × 10<sup>−3</sup>); significant differences were observed only between bronchitis and pneumonia (<i>p</i> = 0.0171); the QALY loss was not age-dependent. Although an increasing tendency in the utility score was observed, a strong cumulative effect related to the length of stay was noted until day 13. Conclusions: RSV contributes significantly to the utility deterioration and QALY loss in the case of RSV hospitalization, and the patient-reported data should be used in pharmacoeconomic assessments of the impact of RSV.https://www.mdpi.com/2079-9721/11/3/111respiratory syncytial virusbronchiolitispneumoniaburdencaregiverinfant |
| spellingShingle | August Wrotek Oliwia Wrotek Teresa Jackowska The Impact of RSV Hospitalization on Children’s Quality of Life Diseases respiratory syncytial virus bronchiolitis pneumonia burden caregiver infant |
| title | The Impact of RSV Hospitalization on Children’s Quality of Life |
| title_full | The Impact of RSV Hospitalization on Children’s Quality of Life |
| title_fullStr | The Impact of RSV Hospitalization on Children’s Quality of Life |
| title_full_unstemmed | The Impact of RSV Hospitalization on Children’s Quality of Life |
| title_short | The Impact of RSV Hospitalization on Children’s Quality of Life |
| title_sort | impact of rsv hospitalization on children s quality of life |
| topic | respiratory syncytial virus bronchiolitis pneumonia burden caregiver infant |
| url | https://www.mdpi.com/2079-9721/11/3/111 |
| work_keys_str_mv | AT augustwrotek theimpactofrsvhospitalizationonchildrensqualityoflife AT oliwiawrotek theimpactofrsvhospitalizationonchildrensqualityoflife AT teresajackowska theimpactofrsvhospitalizationonchildrensqualityoflife AT augustwrotek impactofrsvhospitalizationonchildrensqualityoflife AT oliwiawrotek impactofrsvhospitalizationonchildrensqualityoflife AT teresajackowska impactofrsvhospitalizationonchildrensqualityoflife |