Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males
<p>Abstract</p> <p>Background</p> <p>Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the as...
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BMC
2012-08-01
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| Series: | BMC Medical Genetics |
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| Online Access: | http://www.biomedcentral.com/1471-2350/13/74 |
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| author | Dong Qing Tang Genfu He Mingli Cai Yunqing Cai Yefeng Xing Houxun Sun Liming Li Jianping Zhang Yan Fan Fangfang Wang Binyan Sun Ningling Liu Lisheng Xu Xiping Hou Fanfan Shen Hongbing Xu Xin Huo Yong |
| author_facet | Dong Qing Tang Genfu He Mingli Cai Yunqing Cai Yefeng Xing Houxun Sun Liming Li Jianping Zhang Yan Fan Fangfang Wang Binyan Sun Ningling Liu Lisheng Xu Xiping Hou Fanfan Shen Hongbing Xu Xin Huo Yong |
| author_sort | Dong Qing |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (<it>MTHFR</it>) <it>C677T</it> gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.</p> <p>Methods</p> <p>A total of 18 814 hypertensive patients (6 914 males, 11 900 females) were included in the study.</p> <p>Results</p> <p>Association between the eGFR and <it>MTHFR C677T</it> genotype was examined by sex-specific regression analyses. In males, TT genotype was associated with 1.37 ml/min/1.73 m<sup>2</sup> decrease in eGFR (p = 0.004) and with an increased risk (OR = 1.32, p = 0.008) for the lowest quintile of eGFR after adjusting for age, BMI, and blood pressures. However, such association was not observed in females (p > 0.05). This association suggests <it>MTHFR C677T</it> polymorphism may play a role in the regulation of eGFR in males.</p> <p>Conclusions</p> <p><it>MTHFR 677 T</it> is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease (CKD).</p> |
| first_indexed | 2024-04-11T19:03:54Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-04-11T19:03:54Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
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| series | BMC Medical Genetics |
| spelling | doaj.art-48f7a50e13d34b9cac23db1043c3bf9b2022-12-22T04:07:53ZengBMCBMC Medical Genetics1471-23502012-08-011317410.1186/1471-2350-13-74Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese malesDong QingTang GenfuHe MingliCai YunqingCai YefengXing HouxunSun LimingLi JianpingZhang YanFan FangfangWang BinyanSun NinglingLiu LishengXu XipingHou FanfanShen HongbingXu XinHuo Yong<p>Abstract</p> <p>Background</p> <p>Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (<it>MTHFR</it>) <it>C677T</it> gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.</p> <p>Methods</p> <p>A total of 18 814 hypertensive patients (6 914 males, 11 900 females) were included in the study.</p> <p>Results</p> <p>Association between the eGFR and <it>MTHFR C677T</it> genotype was examined by sex-specific regression analyses. In males, TT genotype was associated with 1.37 ml/min/1.73 m<sup>2</sup> decrease in eGFR (p = 0.004) and with an increased risk (OR = 1.32, p = 0.008) for the lowest quintile of eGFR after adjusting for age, BMI, and blood pressures. However, such association was not observed in females (p > 0.05). This association suggests <it>MTHFR C677T</it> polymorphism may play a role in the regulation of eGFR in males.</p> <p>Conclusions</p> <p><it>MTHFR 677 T</it> is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease (CKD).</p>http://www.biomedcentral.com/1471-2350/13/74<it>MTHFR C677T</it> polymorphismeGFRCKD |
| spellingShingle | Dong Qing Tang Genfu He Mingli Cai Yunqing Cai Yefeng Xing Houxun Sun Liming Li Jianping Zhang Yan Fan Fangfang Wang Binyan Sun Ningling Liu Lisheng Xu Xiping Hou Fanfan Shen Hongbing Xu Xin Huo Yong Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males BMC Medical Genetics <it>MTHFR C677T</it> polymorphism eGFR CKD |
| title | Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males |
| title_full | Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males |
| title_fullStr | Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males |
| title_full_unstemmed | Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males |
| title_short | Methylenetetrahydrofolate reductase <it>C677T</it> polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males |
| title_sort | methylenetetrahydrofolate reductase it c677t it polymorphism is associated with estimated glomerular filtration rate in hypertensive chinese males |
| topic | <it>MTHFR C677T</it> polymorphism eGFR CKD |
| url | http://www.biomedcentral.com/1471-2350/13/74 |
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