<i>N</i>′-Substituted 4-Phenylpicolinohydrazonamides with Thiosemicarbazone Moiety as New Potential Antitubercular Agents: Synthesis, Structure and Evaluation of Antimicrobial Activity

<i>N</i>′-Substituted 4-Phenylpicolinohydrazonamides with Thiosemicarbazone Moiety as New Potential Antitubercular Agents: Synthesis, Structure and Evaluation of Antimicrobial Activity

Three new 4-phenylpicolin derivatives with a thiosemicarbazone structure were synthesized and evaluated for tuberculostatic activity. The compounds were obtained by the condensation of methyl 4-phenylpicolonimidate with the corresponding cycloalkylamino-1-carbothiohydrazides. The <sup>1</su...

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Main Authors: Katarzyna Gobis, Małgorzata Szczesio, Andrzej Olczak, Ida Mazerant-Politowicz, Dagmara Ziembicka, Barbara Pacholczyk-Sienicka, Ewa Augustynowicz-Kopeć, Agnieszka Głogowska, Izabela Korona-Głowniak, Andrzej Fruziński
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Materials
Subjects:
picolinohydrazonamide
thiosemicarbazones
synthesis
temperature NMR
X-ray
ADME
Online Access:https://www.mdpi.com/1996-1944/15/16/5513

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