The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses
Children with asthma are at risk of acute exacerbations triggered mainly by viral infections. A diet high in fruit and vegetables (F&V), a rich source of carotenoids, may improve innate immune responses in children with asthma. Children with asthma (3–11 years) with a history of exacerbations an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/15/3087 |
| _version_ | 1797412693747957760 |
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| author | Banafsheh Hosseini Bronwyn S. Berthon Megan E. Jensen Rebecca F. McLoughlin Peter A. B. Wark Kristy Nichol Evan J. Williams Katherine J. Baines Adam Collison Malcolm R. Starkey Joerg Mattes Lisa G. Wood |
| author_facet | Banafsheh Hosseini Bronwyn S. Berthon Megan E. Jensen Rebecca F. McLoughlin Peter A. B. Wark Kristy Nichol Evan J. Williams Katherine J. Baines Adam Collison Malcolm R. Starkey Joerg Mattes Lisa G. Wood |
| author_sort | Banafsheh Hosseini |
| collection | DOAJ |
| description | Children with asthma are at risk of acute exacerbations triggered mainly by viral infections. A diet high in fruit and vegetables (F&V), a rich source of carotenoids, may improve innate immune responses in children with asthma. Children with asthma (3–11 years) with a history of exacerbations and low F&V intake (≤3 serves/d) were randomly assigned to a high F&V diet or control (usual diet) for 6 months. Outcomes included respiratory-related adverse events and in-vitro cytokine production in peripheral blood mononuclear cells (PBMCs), treated with rhinovirus-1B (RV1B), house dust mite (HDM) and lipopolysaccharide (LPS). During the trial, there were fewer subjects with ≥2 asthma exacerbations in the high F&V diet group (n = 22) compared to the control group (n = 25) (63.6% vs. 88.0%, <i>p</i> = 0.049). Duration and severity of exacerbations were similar between groups. LPS-induced interferon (IFN)-γ and IFN-λ production showed a small but significant increase in the high F&V group after 3 months compared to baseline (<i>p</i> < 0.05). Additionally, RV1B-induced IFN-λ production in PBMCs was positively associated with the change in plasma lycopene at 6 months (r<sub>s</sub> = 0.35, <i>p</i> = 0.015). A high F&V diet reduced asthma-related illness and modulated in vitro PBMC cytokine production in young children with asthma. Improving diet quality by increasing F&V intake could be an effective non-pharmacological strategy for preventing asthma-related illness by enhancing children’s innate immune responses. |
| first_indexed | 2024-03-09T05:06:52Z |
| format | Article |
| id | doaj.art-48f97d8c24fc4e6cb43d9d999894aa8f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T05:06:52Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-48f97d8c24fc4e6cb43d9d999894aa8f2023-12-03T12:53:28ZengMDPI AGNutrients2072-66432022-07-011415308710.3390/nu14153087The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune ResponsesBanafsheh Hosseini0Bronwyn S. Berthon1Megan E. Jensen2Rebecca F. McLoughlin3Peter A. B. Wark4Kristy Nichol5Evan J. Williams6Katherine J. Baines7Adam Collison8Malcolm R. Starkey9Joerg Mattes10Lisa G. Wood11Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre Grow Up Well, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre Grow Up Well, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW 2305, AustraliaChildren with asthma are at risk of acute exacerbations triggered mainly by viral infections. A diet high in fruit and vegetables (F&V), a rich source of carotenoids, may improve innate immune responses in children with asthma. Children with asthma (3–11 years) with a history of exacerbations and low F&V intake (≤3 serves/d) were randomly assigned to a high F&V diet or control (usual diet) for 6 months. Outcomes included respiratory-related adverse events and in-vitro cytokine production in peripheral blood mononuclear cells (PBMCs), treated with rhinovirus-1B (RV1B), house dust mite (HDM) and lipopolysaccharide (LPS). During the trial, there were fewer subjects with ≥2 asthma exacerbations in the high F&V diet group (n = 22) compared to the control group (n = 25) (63.6% vs. 88.0%, <i>p</i> = 0.049). Duration and severity of exacerbations were similar between groups. LPS-induced interferon (IFN)-γ and IFN-λ production showed a small but significant increase in the high F&V group after 3 months compared to baseline (<i>p</i> < 0.05). Additionally, RV1B-induced IFN-λ production in PBMCs was positively associated with the change in plasma lycopene at 6 months (r<sub>s</sub> = 0.35, <i>p</i> = 0.015). A high F&V diet reduced asthma-related illness and modulated in vitro PBMC cytokine production in young children with asthma. Improving diet quality by increasing F&V intake could be an effective non-pharmacological strategy for preventing asthma-related illness by enhancing children’s innate immune responses.https://www.mdpi.com/2072-6643/14/15/3087childhood asthmainnate immunityfruit and vegetablescarotenoids |
| spellingShingle | Banafsheh Hosseini Bronwyn S. Berthon Megan E. Jensen Rebecca F. McLoughlin Peter A. B. Wark Kristy Nichol Evan J. Williams Katherine J. Baines Adam Collison Malcolm R. Starkey Joerg Mattes Lisa G. Wood The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses Nutrients childhood asthma innate immunity fruit and vegetables carotenoids |
| title | The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses |
| title_full | The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses |
| title_fullStr | The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses |
| title_full_unstemmed | The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses |
| title_short | The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses |
| title_sort | effects of increasing fruit and vegetable intake in children with asthma on the modulation of innate immune responses |
| topic | childhood asthma innate immunity fruit and vegetables carotenoids |
| url | https://www.mdpi.com/2072-6643/14/15/3087 |
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